Protein Info for ABZR87_RS19825 in Ralstonia sp. UNC404CL21Col

Annotation: sugar phosphate isomerase/epimerase and 4-hydroxyphenylpyruvate domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01261: AP_endonuc_2
  • amino acids 26 to 270 (245 residues), 144.1 bits, E=9.7e-46
• PF14696: Glyoxalase_5
  • amino acids 284 to 420 (137 residues), 107.8 bits, E=7.9e-35
• PF00903: Glyoxalase
  • amino acids 436 to 548 (113 residues), 23.9 bits, E=6.9e-09

Best Hits

KEGG orthology group: K00457, 4-hydroxyphenylpyruvate dioxygenase [EC: 1.13.11.27] (inferred from 92% identity to rpf:Rpic12D_4415)

Predicted SEED Role

"4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)" in subsystem Aromatic amino acid degradation or Homogentisate pathway of aromatic compound degradation or Plastoquinone Biosynthesis or Tocopherol Biosynthesis (EC 1.13.11.27)

MetaCyc Pathways

• L-tyrosine degradation I (5/5 steps found)
• plastoquinol-9 biosynthesis I (1/3 steps found)
• superpathway of plastoquinol biosynthesis (2/5 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (4/9 steps found)
• vitamin E biosynthesis (tocopherols) (1/7 steps found)

KEGG Metabolic Maps

• Phenylalanine metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.13.11.27

Use Curated BLAST to search for 1.13.11.27

Protein Sequence (627 amino acids)

>ABZR87_RS19825 sugar phosphate isomerase/epimerase and 4-hydroxyphenylpyruvate domain-containing protein (Ralstonia sp. UNC404CL21Col)
MNPPRAARHPKCIATVCLSGTLPEKLEAAAAAGFDGIEMFENDLLNFDGSPARVRQMAAD
LGLAIMLYQPFRDFEAMPREFLARNLARAERKFDVMAELGVEMVLVCSNIQDIAIDDPAR
AADDLRQMAEAAAQRGLRVGYEALAWARHTRTWRQAWQIVKQADHPALGLILDSFHTLSL
GDSLDGLNEVPADKLFFVQFADAPKLSMDVLSWSRHHRNFPGQGELAVTAFARDLLAAGY
TGPLSLEVFNDEFRAAPARLTALDGMRSLRWLESEAGGAPLPTPARFGGVDFLEFAVDAA
AGHELETRLRALGFTLAGHHRSKAVDLYRQGGVNVILNMEQDSAASEHFELHGASVCAIG
LKVDDAERAMTRARELCAQEWRGPVGPRERSIPALRAPDGTLLYLIDDRQADRSIYESDF
VLLPQVQDEAAGWASIDHVAQALPAHRLDSFVLFYRAIFGMQAEAMQEIADPYGLVKSRA
MVSPDRNVRIPLSVSESGRTATGRFIAAYAGSGVHHIAFRTERLFETIEAIDRSAAHLQH
VPENYYDDVAARLGLDDALVTRLHDDGLLYDRDPHGDFLHTYTEPFRERFFFELVQRNGY
LGYGAANAAVRMAVQAQLSREHANAGG