Protein Info for ABZR87_RS19795 in Ralstonia sp. UNC404CL21Col

Annotation: gamma-glutamyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00066: gamma-glutamyltransferase
  • amino acids 30 to 529 (500 residues), 569.1 bits, E=4e-175
• PF01019: G_glu_transpept
  • amino acids 45 to 562 (518 residues), 582.3 bits, E=5.1e-179

Best Hits

Swiss-Prot: 81% identical to GGT_PSEUA: Glutathione hydrolase proenzyme (ggt) from Pseudomonas sp. (strain A14)

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 98% identity to rpi:Rpic_4299)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

• γ-glutamyl cycle (4/6 steps found)
• glutathione degradation (DUG pathway) (1/2 steps found)
• leukotriene biosynthesis (1/6 steps found)
• hypoglycin biosynthesis (4/14 steps found)
• peptido-conjugates in tissue regeneration biosynthesis (3/17 steps found)

KEGG Metabolic Maps

• Arachidonic acid metabolism
• Cyanoamino acid metabolism
• Glutathione metabolism
• Selenoamino acid metabolism
• Taurine and hypotaurine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.2.2

Use Curated BLAST to search for 2.3.2.2

Protein Sequence (569 amino acids)

>ABZR87_RS19795 gamma-glutamyltransferase (Ralstonia sp. UNC404CL21Col)
MRWIAAAIASISITTVAHAASVAPVAAENGMVVSAQHLASKVGVEVLKRGGNAVDAAVAV
GYALAVVYPAAGNLGGGGFMTIQLADGRKTFLDFREVAPKAATANMYLDKDGNVIKGAST
KGHLAVGVPGTVSGMEYARQKYGTMQRAALIAPSIALAEKGFTLDQGDVDMLHTSTKDFQ
EDAASGAIFLNKGQPFQVGEKLVQRDLAKTLREISNKGTDGFYKGWVGQAIAASSKAGGG
LITQEDLVSYKTRELAPVECDYRGYHVVSAPPPSSGGVIICEMLNILEGYPLKDLGWHSA
QATHYQIEAMRHAYVDRNSYLGDPDFVKNPLDRLLSKDYAAKIRAVIDPKKAGVSKDIKP
GVEPHEGSNTTHYSIADKYGNAVSVTYTLNDWFGAKVTAAKTGVILNDEMDDFTAKVGVP
NLYGLVQGEANSIAPGKRPLSSMSPTIVTKDGKPVMVVGTPGGSRIITAVMLTMINAIDY
GMNVQEAVDMPRFHQQWLPDVTNVEPYALSDDTRKILTSMGHNLGAPQPANHLAAIIVGA
PSLGGKPVGNNRFYGANDPRRNTGLAAGY