Protein Info for ABZR87_RS19695 in Ralstonia sp. UNC404CL21Col

Annotation: FdhF/YdeP family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01701: oxidoreductase alpha (molybdopterin) subunit
  • amino acids 13 to 762 (750 residues), 1002.7 bits, E=5e-306
• PF00384: Molybdopterin
  • amino acids 109 to 544 (436 residues), 98.2 bits, E=5.3e-32
• PF01568: Molydop_binding
  • amino acids 649 to 755 (107 residues), 26.8 bits, E=4.5e-10

Best Hits

KEGG orthology group: K00123, formate dehydrogenase, alpha subunit [EC: 1.2.1.2] (inferred from 97% identity to rpf:Rpic12D_4390)

Predicted SEED Role

"Putative formate dehydrogenase oxidoreductase protein" in subsystem Formate hydrogenase

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Protein Sequence (779 amino acids)

>ABZR87_RS19695 FdhF/YdeP family oxidoreductase (Ralstonia sp. UNC404CL21Col)
MKHQKIEFYRHPAGGWGALKSVAHQLLSQGIAAKGAKTMLSANQPDGFDCPGCAWPDRDH
ASTFEFCENGVKAVAAEATSRRTTPEFFAQHTVRELAEWSDYALEDQGRLTHPMVYNAAS
DKYVPIEWDAAFALIAQHLRALPDPNQAIFYTSGRTSNEAAFLYQLFVRAYGTNNFPDCS
NMCHEPSGTGMRSSIGVGKGTVTLDDFTKADAIFIFGQNPGTNHPRMLGELREASKRGAK
IVSFNPLRERGLERFADPQSKIEMLTLGSTRISTEYHQVRIGGDLATVKGIIKHVIERDD
VARSRGEPAIIDHAFIAQHTGGYDAFAADVRAESWATIEAESGLPEHEIRQAGDTYIKAG
SVIACWGMGITQHKHSVATIQMIVNLLLLRGNIGRPGAGACPVRGHSNVQGDRTMGIYEK
PAPAFLDRLEHVFGIQVPREHGYDTVGAIEAMQQGNARVFFAMGGNFAAATPDTAATWAG
LRQCDLTVHVTTKLNRSHIVHGKAALILPCLGRTEIDQQAGGTQGVTVEDSMSMVHMSAG
INPPASPHLLSEPAIVARLAEATLPESTIPWRWLVEDYDRIRERIEAVFDDFAGFNEKIR
VPGGFRLRNTASERVWNTPSGKAEFHAHAVPTDTPVHRARERHADATVFTLATVRSHDQY
NTTIYGMDDRYRGVFGQRRVVFINKEDLHTIRMKDGEWVDMVTLSEDGTTRRADGFRLVA
YDIPRGCLAAYYPETNPLVPLSSVADQARTPTSKSIPVMLVPSQAERTADATAANTAEA