Protein Info for ABZR87_RS19635 in Ralstonia sp. UNC404CL21Col

Annotation: cation:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 703 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 35 to 54 (20 residues), see Phobius details amino acids 74 to 91 (18 residues), see Phobius details amino acids 103 to 123 (21 residues), see Phobius details amino acids 128 to 152 (25 residues), see Phobius details amino acids 170 to 192 (23 residues), see Phobius details amino acids 204 to 228 (25 residues), see Phobius details amino acids 231 to 232 (2 residues), see Phobius details amino acids 246 to 248 (3 residues), see Phobius details amino acids 253 to 273 (21 residues), see Phobius details amino acids 287 to 308 (22 residues), see Phobius details amino acids 320 to 348 (29 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 392 to 414 (23 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 11 to 417 (407 residues), 156.5 bits, see alignment E=4.7e-50

Best Hits

KEGG orthology group: K03316, monovalent cation:H+ antiporter, CPA1 family (inferred from 98% identity to rpf:Rpic12D_4378)

Predicted SEED Role

"Na+/H+ antiporter" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (703 amino acids)

>ABZR87_RS19635 cation:proton antiporter (Ralstonia sp. UNC404CL21Col)
MNGVVILLLVAGGLLAVVALVQMLASRLTLPESTLLALAGIGIGGAYVILRSSAPAFATT
FFAPLVDPSWPAEAYLWLFLPPLLFQAALSVDVRSMAPDAAPILMLAIVAVVVATGVIGL
AAAAVTPFGIVTCLLLGAMIATTDPSAVIAVFRDVGAPARLIRLVEGEALLNDAAAIAIM
GVLLAMLTGHGGDASIVAGLRELARAFGGGVVFGLIAGRIAAFLLPALRGIAQAEAAWTL
ALPYPLYLVAENMLGVSGVVSVVCAGLVIGALGRTRLTPRNWSHLQLIWEQIAALAGAVV
FLLAAVRVPELLHGVVWKDALWLAVIVLAALVARLAVLFGLLPALAWLKLSAPVSHAYKL
AIAWGGLRGAVTLVLALGVAENQAVHEADRHFVTILATGFVLVSVLFNGATLRWVMRQLG
LDQLSPQEQALQGQALSMSTEEVESTMRRIGGHFHFTSGATDQAAEVYRREVAAGALELN
LEEALSERERLTIGLVSLATRERELIPEYGNGLVSIRNLDAMMRNTADMIDAARTEGRLG
YKRASRRILAKNAGYRFAVWLHRVAHIDRPLANALADRFELLICRQTVLERLRAYNRTSL
QPVLGERMADLLDGVLITRIEAAEEGLAELREKFGDYSAALEKRLLVLFALYIGQSKIDT
MLAETVISKEVYKQISAVIRRAWTAALPRPPLSTALRMPAASR