Protein Info for ABZR87_RS19620 in Ralstonia sp. UNC404CL21Col

Annotation: PepSY-associated TM helix domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03929: PepSY_TM
  • amino acids 7 to 362 (356 residues), 197.3 bits, E=2.7e-62

Best Hits

KEGG orthology group: K00380, sulfite reductase (NADPH) flavoprotein alpha-component [EC: 1.8.1.2] (inferred from 93% identity to rpf:Rpic12D_4375)

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Protein Sequence (380 amino acids)

>ABZR87_RS19620 PepSY-associated TM helix domain-containing protein (Ralstonia sp. UNC404CL21Col)
MLRRVLFRLHWLIGLSASVVLAIVGATGALMAYEDELLRALNPGVLTLPARSGPAPTLLQ
VAAQARAAMPKRPVTFITAASAPTEPWRVWYAWPPGKHGGSSRGELRYIDAATGTLLPEA
RAQHFFATVKLLHRTLLADEIGKQIVGASTVGLVVMALSGLYLRWPRRVTNWRSWLVIRW
SRAGRIRWWDVHTVLGTLVLPLYLLAAFSGLYWAYDWYRDGLQRLAGMPVVTKAKPVEGA
RQPLDGAALERTWNVFLANASNYGTATLRIDDARTGKVDINWLPADAPHDRAFNRLTLDA
STGVVIRNESFADKPPMQRLLAGMLPLHNGRYFGPIGVVLVLIGALMLPVFAATGWWLYL
DRRRRAQPQRKHASAATRPC