Protein Info for ABZR87_RS18640 in Ralstonia sp. UNC404CL21Col

Annotation: ATP-dependent helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 716 PF00580: UvrD-helicase" amino acids 24 to 315 (292 residues), 206.4 bits, see alignment E=2.1e-64 PF13245: AAA_19" amino acids 40 to 301 (262 residues), 76.6 bits, see alignment E=6.3e-25 PF13361: UvrD_C" amino acids 323 to 477 (155 residues), 79.1 bits, see alignment E=1.4e-25 amino acids 573 to 645 (73 residues), 61.6 bits, see alignment E=2.8e-20 PF13538: UvrD_C_2" amino acids 589 to 643 (55 residues), 41 bits, see alignment 4.2e-14

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 98% identity to rpf:Rpic12D_4241)

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA, proteobacterial paralog" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (716 amino acids)

>ABZR87_RS18640 ATP-dependent helicase (Ralstonia sp. UNC404CL21Col)
MLAASPTPDTATVPATPGYLAQLNDQQRQAVEFGISGADAAETGPLLVLAGAGSGKTHTL
GWRVAHLVANGADPQRILLLTFSRRAASELSNRAGHLLARAMQGERSNHALNSAGTSYKT
TLPWAGTFHGIGARLLREYADRVGLAPDFTIHDRSDSADLLNVVRHELNLSTKERRFPLK
QTCIAIYSRAINAESSLNAVLKHHFPWCAMWETQLRTLFDAYVEAKQAQHVLDYDDLLLY
WHAMVSDAELAAEIGARFDHILVDEYQDTNRLQSSILRALRPDGRGVTVVGDDAQSIYAF
RAATVRNILDFPRHFSRPAHTVLLERNYRSTQPILDASNGVMRFATERFAKTLWTDRAST
HRPRLISVRDEAEQARCVAERVLHHREGGLTLKSQAVLFRTASHSAPLEIELTRRNIPFV
KYGGLKFLEAAHVKDVLSVLRWAENPRNRIAGFRVIQLLPGAGPATAARVLDAMAEAADP
IAALLAYEPPARLAGDWSALMALMQTLRTPKDSLEWAAELEAVGAWYAPHMERLHDDAAV
RQGDLDQLARMATTYATRERFLTEMTLDPPELTSDESGDPYRDEDYLILSTIHSSKGQEW
KAVYVLNAVDGCMPADLGAGSHEELEEERRLLYVAMTRAREHLDILVPQRFYVTQQTPNG
DRHIYASRTRFIPPALLPLFEACAWPEPEPGADPAAEARAAAKVDLSKKMRGYWKK