Protein Info for ABZR87_RS18625 in Ralstonia sp. UNC404CL21Col

Annotation: sensor domain-containing diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 348 PF01590: GAF" amino acids 28 to 155 (128 residues), 72.9 bits, see alignment E=5.6e-24 PF13185: GAF_2" amino acids 28 to 152 (125 residues), 31.4 bits, see alignment E=3.2e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 179 to 342 (164 residues), 157.2 bits, see alignment E=1.6e-50 PF00990: GGDEF" amino acids 182 to 340 (159 residues), 134.5 bits, see alignment E=4.5e-43

Best Hits

KEGG orthology group: None (inferred from 94% identity to rpf:Rpic12D_4238)

Predicted SEED Role

"FOG: GGDEF domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (348 amino acids)

>ABZR87_RS18625 sensor domain-containing diguanylate cyclase (Ralstonia sp. UNC404CL21Col)
MKPAPIPTNEPERLASLQDMLLLSTPDEELFDRVTRTTKRVFDAPIVLVSLIDAQRQWFK
SCIGLNVRETGRDISFCGHAVAEEQMLVIPDTKADPRFADNPLVTGAPHIRFYAGRPVKN
LAGYAVGTLCVIDQKPRPFEQAERELLNDLASWVESGFRERELSESQRSILTELQVARHE
SLTDPMLGIWNRRAAMELLTRECGHAMLHGQPLSLLVVDVDHFKRVNDTYGHPAGDAVLV
EIARTLRVNSRPVDAVGRYGGEEFLVVLPDTTTLQATGIAQRLRSAVESLEIATPEANIR
CTISVGLASCEAGRNLCTPTDLIMRADAALLAAKRLGRNRVIFDGQPV