Protein Info for ABZR87_RS18455 in Ralstonia sp. UNC404CL21Col
Annotation: shikimate dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to AROE_NITMU: Shikimate dehydrogenase (NADP(+)) (aroE) from Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 83% identity to bac:BamMC406_6247)MetaCyc: 48% identical to shikimate dehydrogenase (Escherichia coli K-12 substr. MG1655)
Shikimate dehydrogenase. [EC: 1.1.1.25]
Predicted SEED Role
"Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- superpathway of L-phenylalanine biosynthesis (10/10 steps found)
- superpathway of L-tyrosine biosynthesis (10/10 steps found)
- chorismate biosynthesis I (7/7 steps found)
- superpathway of chorismate metabolism (44/59 steps found)
- chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
- chorismate biosynthesis II (archaea) (8/12 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.25
Use Curated BLAST to search for 1.1.1.25
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (277 amino acids)
>ABZR87_RS18455 shikimate dehydrogenase (Ralstonia sp. UNC404CL21Col) MTDHYAVIGNPISHTKSPLIHGLFAQEARQDMEYTAIEGPVEPDTAFADVVRTFAAGGGK GMNVTAPFKLKAFAMADERSERATLAGAVNAMKFEGGRILADNFDGIGLVRDIEINLGLP MSGKRVLMLGAGGAARGALLPFLEAKPAELVIANRDFAKAQALAAQVAGRGVVVACGYAE LEGMGRFDLVVNATSASLTGDLPPVPPSIFRPEGMAYELAYGKRLTPFLRLARNAGVRNL ADGVGMLVEQAAEAFAWWRGVRPDTRPVIDRLTVPLD