Protein Info for ABZR87_RS17960 in Ralstonia sp. UNC404CL21Col

Annotation: chemotaxis protein CheA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 PF01627: Hpt" amino acids 8 to 107 (100 residues), 64.5 bits, see alignment E=2.2e-21 PF09078: CheY-binding" amino acids 178 to 239 (62 residues), 76.8 bits, see alignment 2.7e-25 PF02895: H-kinase_dim" amino acids 307 to 369 (63 residues), 70.6 bits, see alignment E=3.1e-23 PF02518: HATPase_c" amino acids 417 to 553 (137 residues), 65.5 bits, see alignment E=1.4e-21 PF01584: CheW" amino acids 559 to 688 (130 residues), 102.5 bits, see alignment E=3.8e-33

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 98% identity to rpi:Rpic_4048)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (724 amino acids)

>ABZR87_RS17960 chemotaxis protein CheA (Ralstonia sp. UNC404CL21Col)
MNLDLSQFFGAFFEEAEELLVDMERLLLNLDVANPSSDDLNAIFRCAHSIKGGAATFGFT
HMTELTHVAESILDRARTGTLQLRENMVDAFLETKDVLKSQLDAYRQEHPIDTATLEYMV
AKLNSLTAEDGAPVAAAPAAAAPVAATPEPVVAPQPEPVVVEAPAAEVVGDIEGGLDIKL
IDVSNEDCELIVTELKHLGTVLRHARTGRNSDIVLQSTCTADDIIAVSCFIIDADQIVIT
PHVGGVAPAAEAAAPVVAAPTPAAAQTEVHAPAANEAAPAQPVAAVAAPMPTRPAAADHK
PAVAAETSIRVGVEKVDQLINLVGELVITQAMLAQTAQAFDPVLNERLFAGLSQLTRNAR
DLQEAAMSIRMMPMDYVFNRFPRLVRDLAHKLGKQVELSTFGKSTELDKGLIERIIDPLT
HLVRNSLDHGIELPEARVAAGKDATGQLLLSAAHQGGNIVIEVSDDGQGLNRDKILKKAR
ERGLPVSDNMTDDEINQLIFAPGFSTADQVTDVSGRGVGMDVVKQNIQSMGGYVEIQSQK
GKGTTIRIVLPLTLAILDGMSVKTGDEVFILPLSCVAESLQPRPEDIKAVPGGGRLLKVR
NEYLTLVPMYERFRITPSLPDPSEGIVVILDSEGKKIALQVDELVGQQQVVVKNLETNYR
RVPGISGATILGDGSVALIVDVSALMRETRAGHSENAMRAVTAEKHEMGEAQGGRFSTEA
MAAA