Protein Info for ABZR87_RS16770 in Ralstonia sp. UNC404CL21Col

Annotation: HD domain-containing phosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 980 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 350 to 371 (22 residues), see Phobius details PF13487: HD_5" amino acids 780 to 937 (158 residues), 147.9 bits, see alignment E=2.6e-47 PF01966: HD" amino acids 834 to 903 (70 residues), 25.5 bits, see alignment 1.4e-09

Best Hits

KEGG orthology group: None (inferred from 60% identity to rme:Rmet_3876)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (980 amino acids)

>ABZR87_RS16770 HD domain-containing phosphohydrolase (Ralstonia sp. UNC404CL21Col)
MQMRRRYPLHVHLWVLFGALVLVLGALICGIHFLMSKAERERAATEATHRISRETLDEVQ
DLFAPAQMAVKLVSHSSLADAVSNDERLERLALVRDALDTSPVLQSLYVGYDDGSFFYVR
PLRETADRDVFKAPSQAAYVVRTVERAGNVAQGKLTFLDAGLAVVKTVDASDFAERFDPR
QRPWYVSAITKGGLIRTEPYMFFSDRQAGATLAVPTASRRAVVGGDVRLDLLGRMLARKE
TVERGLLALLDANGQVIAIDRSPPASASAPDNILSGLLAAPADYGLPVLTQLAANLRSPG
ASPTGQALISAGGEAWYTSTDQLTPTGGTPLFLISAVPQDELLKDARRQAWLGIGATGLV
ILFSLPLIWWSARRIAHPMEALADGMDAIRHFDFQQPIAVRSSISEVSALGETSEHMRQT
IQRFLTIVQAVSAEARLEQLLPVLLRKMLNAAGGSAGVLYLANDDALNARVAFDRAGNDV
ASMIVPAGQDQALPLIRFTAGAMTPRAGVITPDDIRAAGLAPLTADASCHAAAVPLVTRE
HALQGVILVLRDTPIEPAQLAFVGMLANLCAGALEVRELSEAQRKLFDAFIQVMAGAIDA
KSPHTGGHCGRVPELAKMLAHAACDATDGPYKAFQMTEAQWHALHVAAWLHDCGKVTTPE
YVIDKATKLETLHDRIHEVRMRFEVLKRDAEIACLHAIAAGEPPDIARHRRDTELAALDD
DFRFVATCNLGGEFMDAPQKERLLRIATRTWTRTLDDRLGVSQEELARKARHPAPPLPTA
EPLLADKPEHVIERTAHDTIAPANPWGFKLNTPAHLYDRGELHNLMVSRGTLSEEERFKI
EDHIVQTQIMLSRMPFPKALRDVPEIAGNHHEKMDGTGYPRRLRREQMSPLARMMAIADV
FEALTAADRPYKKAKTLSESVRIMAMARDQQHIDPELFDLFLSSGVYLRYAERFMQPEQI
DAVNVAQYVRGAEAASQSAA