Protein Info for ABZR87_RS16760 in Ralstonia sp. UNC404CL21Col

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 287 to 446 (160 residues), 150.5 bits, see alignment E=1.8e-48 PF00990: GGDEF" amino acids 288 to 444 (157 residues), 142.7 bits, see alignment E=4.6e-46

Best Hits

KEGG orthology group: K13590, diguanylate cyclase (inferred from 96% identity to rpf:Rpic12D_3978)

Predicted SEED Role

"diguanylate cyclase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (448 amino acids)

>ABZR87_RS16760 GGDEF domain-containing protein (Ralstonia sp. UNC404CL21Col)
MTENNPSETARHALKLLASRRLAPTPDNFASIYYEIAGSKPDADAQDAERMALVRELCEQ
LARTVEGCLPVLGEDDASIGPAAWALIRACRSEFESLANLNAKLSTFNHRLSLAAEDQSE
IRRALLSLLQLVFENIAELSLDDRWLRGQIEALMKASEAPVSLRRLDDLRRRLMEVIQKQ
SSLKSKSLEAQEEMKRLLAAFMERLSAAAETSGEHHRQMEACAKKIESANSIADIAPAIQ
DALSATRWMSLESARNRDVLSAMKVKAEEAAAEVAQLRKALDMASASARHDLLTGALNRK
GLEEALEREVARAARQNSALSIAFLDIDDFKSINDTHGHSFGDDALSHLAQVARESMRPQ
DTLARFGGEEFVILMPDTSLEEGVQTIVRLQRALTQRFFAAGDTRLFITFSAGVAEVGKA
EPPMAAIHRADRGMYQAKRAGKNKVVSA