Protein Info for ABZR87_RS16630 in Ralstonia sp. UNC404CL21Col

Annotation: 2-oxoglutarate dehydrogenase E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 857 TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 26 to 852 (827 residues), 814.7 bits, see alignment E=5e-249 PF00676: E1_dh" amino acids 194 to 418 (225 residues), 123.2 bits, see alignment E=1.6e-39 PF02779: Transket_pyr" amino acids 508 to 704 (197 residues), 133.1 bits, see alignment E=1.3e-42 PF16870: OxoGdeHyase_C" amino acids 712 to 853 (142 residues), 135.5 bits, see alignment E=2e-43

Best Hits

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 79% identity to rso:RSp1364)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.4.2

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (857 amino acids)

>ABZR87_RS16630 2-oxoglutarate dehydrogenase E1 component (Ralstonia sp. UNC404CL21Col)
MADPGPAAGFDLSNAPAGPATALPLTPVTQLIDAYREHGHRRARLDPLARVPLPDVPELR
LRFHGLDPAQKCDPASAVLPTATTMQELEWQLKRVYCGAIGLDCSSVRKRQRRAWLYARM
EAELLAPPLAPDQKRTLLRRLVAAEMWERLVGGTFAHAKRFSLEGCESLVPLLDALVEEG
AGHGVRQVFLGMPHRGRLNTLVNVMGFGARGMLDRLDPDSDIAFTQRDLPYHLGDVARRM
VAGDEVSLVLAPNPSHLQSVYAVVCGMARAHVDEHPGTPCLPVMVHGDAAFAGQGVVMET
LNLTRRSGYTAGGVVHVIVNNQIGFTTPNLMDVRAHDYCTDVTRMVDAPVLHVNADDPEA
VMRAARIAIAYRMEHGADIVIDLIGYRRLGHSEHDTPAVTQPALHAAIAAHPTVTELYHA
ASAEPARLADLRDAAVRDLHAGPGAAPGEADASLPHGAARRQLQPLSLHRVQVLTQTLTT
PPDGVLLHDVVRGLCERWRTAVSSGAHTVDWCLAENLAHATLLEDGQSIRLSGMDVGRGT
FMHRHAVWHSQATLSDEGRRYVPLQHVAPCQGTFDIVNSPLSEEAALGFEYGYSVQTRSR
LTLWEAQFGDFVNGAQVFIDQYIASGEYKWGCQSALAMLLPHGHEGVGPEHSNGFLGRFL
QLCADDNMRVVMPSTSGQWFHLLREQAALATPKPLIVMSPKTQLHGNGRSHSRVQDLIDG
CFMPVLADASVVDGQTVTRVVLCSGKFFYELQAQREREARTDVALVRVEQVYPFPQEALA
AALAVFPNLKEIVWAQEEDANQGAWRFVREALEACVPQGSRLTGVCRSATPSGAHASVRA
HQAEQRRLVAAALGAMG