Protein Info for ABZR87_RS16395 in Ralstonia sp. UNC404CL21Col

Annotation: prolyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 317 TIGR01249: prolyl aminopeptidase" amino acids 12 to 314 (303 residues), 379.5 bits, see alignment E=5.5e-118 PF00561: Abhydrolase_1" amino acids 41 to 297 (257 residues), 101.3 bits, see alignment E=7.3e-33 PF12146: Hydrolase_4" amino acids 62 to 297 (236 residues), 45.1 bits, see alignment E=8.1e-16

Best Hits

Swiss-Prot: 63% identical to PIP_SERMA: Proline iminopeptidase (pip) from Serratia marcescens

KEGG orthology group: K01259, proline iminopeptidase [EC: 3.4.11.5] (inferred from 92% identity to rpi:Rpic_3807)

Predicted SEED Role

"Proline iminopeptidase (EC 3.4.11.5)" in subsystem Proline, 4-hydroxyproline uptake and utilization (EC 3.4.11.5)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.5

Use Curated BLAST to search for 3.4.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (317 amino acids)

>ABZR87_RS16395 prolyl aminopeptidase (Ralstonia sp. UNC404CL21Col)
MSALRTLYPPIEPYETGMLDVGDGHTIYYERVGTPGAKPAVFLHGGPGGGVSADHRRVFD
PARYDVMLFDQRGCGRSTPHAGLEANTTWHLVADIERLRAIAGADRWLVFGGSWGSTLAL
AYAQKYPQHVSELVLRGIYTVTQAELRWYYQYGVSEMFPEKWARFQAPIPEAQRGDMIAA
YRKVLTGNDTARQIEAARAWSVWEGETITLLPDPANSAKHADDHFALAFARLENHYFTHQ
CWLEEGQLLREAHRLAGIPGVIVHGRYDMPCPARYAYALHHAWPDSDFHLIEGAGHAWSE
PGILDQLLAATDRFAGK