Protein Info for ABZR87_RS15705 in Ralstonia sp. UNC404CL21Col

Annotation: UvrD-helicase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 786 PF00580: UvrD-helicase" amino acids 8 to 274 (267 residues), 288.5 bits, see alignment E=2e-89 PF13245: AAA_19" amino acids 12 to 260 (249 residues), 81.7 bits, see alignment E=1.7e-26 PF13361: UvrD_C" amino acids 280 to 647 (368 residues), 263.2 bits, see alignment E=1.4e-81 PF13538: UvrD_C_2" amino acids 588 to 643 (56 residues), 35.6 bits, see alignment 2e-12 PF21196: PcrA_UvrD_tudor" amino acids 737 to 784 (48 residues), 29 bits, see alignment 2.4e-10

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 100% identity to rpi:Rpic_2440)

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (786 amino acids)

>ABZR87_RS15705 UvrD-helicase domain-containing protein (Ralstonia sp. UNC404CL21Col)
MSDLLANLNPEQRAAITLPDESALILAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTF
TNKAAKEMTARLQAMLPINTRAMWIGTFHGLCNRLLRAHFRDAGLPQTFQILDTQDQLSA
VKRLLKSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIANEYDRRMADLYAAYDAQCQR
EGVVDFAELLLRCYELLRYNDAIRAHYQRRFKHILVDEFQDTNKLQYAWLKILAGLGEPG
VTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVEHRIKLEQNYRSHGHILDTANHLI
SHNTRRLGKNLRTDAGHGEPVRVYQAATDGQEAGWIVDEIRDRIATGMSRSEIAILYRSN
AQSRVIEHALFSAGIPYKVYGGLRFFERAEIKHALAYLQLLENPDNDAAFGRVVNFPARG
VGARSLEQLQDAARLYGISLAAAVPYLTGAAGTKLSAFVRLIEQMRADTRQMTLPEIVQH
VIHASGLITHYQGEKEGQDRIENLQELVTAAQAFVAEEGYGVDAIATALPVRHDAMLRIE
GGEIDTASELVTDETPAEMTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFHV
VFITGLEEGLFPHENSQMEKDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQIRYHIR
SRFFDELPEDTLKWLTPQHAGYQATRRVQGDTAWGKDWFKRPERGDDDAYTGRPTGGMDT
GKNYADAKRAEATGFRVGQSVFHNKFGEGVITTLEGEGAEARAQIKFNRHGVKTLALGIA
KLDPIN