Protein Info for ABZR87_RS15505 in Ralstonia sp. UNC404CL21Col

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1172 TIGR00594: DNA polymerase III, alpha subunit" amino acids 6 to 984 (979 residues), 1191.6 bits, see alignment E=0 PF02811: PHP" amino acids 8 to 180 (173 residues), 136.9 bits, see alignment E=2.2e-43 PF07733: DNA_pol3_alpha" amino acids 299 to 569 (271 residues), 350.3 bits, see alignment E=1.9e-108 PF17657: DNA_pol3_finger" amino acids 572 to 736 (165 residues), 216.9 bits, see alignment E=2.7e-68 PF14579: HHH_6" amino acids 811 to 900 (90 residues), 109.6 bits, see alignment 1.7e-35 PF01336: tRNA_anti-codon" amino acids 1007 to 1084 (78 residues), 28.2 bits, see alignment 3.8e-10

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 79% identity to bac:BamMC406_2232)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1172 amino acids)

>ABZR87_RS15505 DNA polymerase III subunit alpha (Ralstonia sp. UNC404CL21Col)
MNSPRFVHLRLHSEYSVVDGNVRLDDAVKAAAKDGMGALALTDLANAFGLVRFYKEARGK
GVKPIVGADVWITNHDERDKPTRLLLLVRDKQGYLNLCQLLARAWLSNQHRGRAEIAPEW
FDEPGVENAPLATGLLALSGAMAGDIGMALANGNDALARKLATHWSRVFPGAFYIELQRA
GHAGTEAYIQQAVKLASAMQLPVVATHPVQFMTPDDFTAHEARTCIAEGELLANPRRARR
FTTEQYFKTQDEMCALFADIPSALANAVQIAQRCNLKLELGKPKLPLFPTPDGMSLDDYL
VQLAKEGLEKRMEVLFPDEAVRESKRAEYYARLEFETGTIIKMGFPGYFLIVADFINWAK
NNGVPVGPGRGSGAGSLVAYALGITDLDPLKYNLLFERFLNPERVSMPDFDIDFCQHGRD
RVIQYVKEKYGKDAVSQIATFGTMAAKAAVRDVGRVLDLGYNFVDGVAKLIPFKPGKLVT
LEEAKKEEPLLAEREANEEEVKQLLELAQRVEGMTRNVGMHAGGVLIAPGKLTDFCPLYT
QGGEDAGVVSQYDKDDVEAVGLVKFDFLGLTTLTILDWAERYIRMLDPSKADWNCSHIPL
TDKKAFDILKTANTVAVFQLESRGMQGMLKDAKPDRFEDIIALVALYRPGPMDLIPSFCA
RKHGREKVEYPDPRVEPVLKETYGIMVYQEQVMQMAQIVGGYSLGGADLLRRAMGKKKPE
EMAQHRELFRAGAAKDGLSTEKADEIFDLMEKFAGYGFNKSHAAAYALLAYYTAWLKAHH
PAEFMAANMSLAMDDTDKVKILYDDARGKNGLTILPPDINASQYRFAPTDAKTIRYGLGG
VKGSGQGAIEDILRAREDGPFKDLFDFCERVDRRQVNRRTIEALVRAGAFDSLNANRAQL
LASIGLAMEAAEQKAAAANQVSLFDLMSGDDAEQHRPELVDEPAWTTKRKLQEEKQALGF
YLSGHLFDEYRDEVRRFARTTLADLAREVTDKGNGGGYGNRDARNKTVAGVIVGQRTQMT
QRGKMLIVMLDDGSASEATEVTVFNEVFEANRALFKEDEVLIVQGSARHDMFTGGVRVTA
ESVMDMTQARAKFARAIRLSMNGDSTAAKLRDLLSPHVAADGNGVSVRINYVCEQARCEA
VLGDAWRIVPSEAAIAALRQALDAENVATVYE