Protein Info for ABZR87_RS15390 in Ralstonia sp. UNC404CL21Col

Annotation: NCS1 family nucleobase:cation symporter-1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 492 transmembrane" amino acids 41 to 62 (22 residues), see Phobius details amino acids 68 to 90 (23 residues), see Phobius details amino acids 117 to 140 (24 residues), see Phobius details amino acids 161 to 180 (20 residues), see Phobius details amino acids 192 to 211 (20 residues), see Phobius details amino acids 238 to 258 (21 residues), see Phobius details amino acids 279 to 301 (23 residues), see Phobius details amino acids 320 to 341 (22 residues), see Phobius details amino acids 357 to 377 (21 residues), see Phobius details amino acids 383 to 408 (26 residues), see Phobius details amino acids 430 to 449 (20 residues), see Phobius details amino acids 468 to 487 (20 residues), see Phobius details TIGR00800: NCS1 nucleoside transporter family" amino acids 23 to 456 (434 residues), 383.8 bits, see alignment E=5.2e-119 PF02133: Transp_cyt_pur" amino acids 28 to 476 (449 residues), 402.5 bits, see alignment E=1.1e-124

Best Hits

KEGG orthology group: K03457, nucleobase:cation symporter-1, NCS1 family (inferred from 99% identity to rpf:Rpic12D_1985)

Predicted SEED Role

"Cytosine/purine/uracil/thiamine/allantoin permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (492 amino acids)

>ABZR87_RS15390 NCS1 family nucleobase:cation symporter-1 (Ralstonia sp. UNC404CL21Col)
MSQTTSSAFSADAAGAPDPTLWNEDLNPTPPAARTWTATNYAALWVSMVVSVPAYMLASG
LMSEGMNWWQAVLTVFLGNLIVLVPMVLVGHAGTKYGIPFPVLVRASFGVRGAQLPAILR
AIVACGWFGIQTWLGSQAIYTILNVVTDNMLVGSNIPGLGINPGQGFCFLLFWALHIWLI
TKGLESIKRFQALATPLLILAALGLVWWAYVHAGGFGPMLSAPSAFSAGGKRAGEFWGFF
WPSLTAMVGYWATLALNIPDFTRFARSQRDQLVGQAIGLPLPMGLLALVAVLVTSSTVVI
YGQAIWDPVTLAGKMTGPSVIVALLALITATLMTNIAANVVSPAYDFSNLAPHRISFRIG
GYITAGIGLAMMPWKILETTKGYIFTWLVGYGALLGPVAGIMMVDYFLVRRTVLKTGELF
RVDGPYGYGNGWNGRAIVALIIGVLPNLPGFFKQAGFVASVPGVFEALYTYAWFVGLAIS
AVVYVLLMRGRR