Protein Info for ABZR87_RS15060 in Ralstonia sp. UNC404CL21Col

Annotation: guanine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02967: guanine deaminase
  • amino acids 33 to 433 (401 residues), 586.3 bits, E=1.5e-180
• PF01979: Amidohydro_1
  • amino acids 75 to 434 (360 residues), 181.9 bits, E=2.2e-57
• PF07969: Amidohydro_3
  • amino acids 223 to 435 (213 residues), 36.7 bits, E=3.8e-13

Best Hits

Swiss-Prot: 48% identical to GUAD_ECOLI: Guanine deaminase (guaD) from Escherichia coli (strain K12)

KEGG orthology group: K01487, guanine deaminase [EC: 3.5.4.3] (inferred from 97% identity to rpf:Rpic12D_1926)

MetaCyc: 48% identical to guanine deaminase (Escherichia coli K-12 substr. MG1655)
Guanine deaminase. [EC: 3.5.4.3]

Predicted SEED Role

"Guanine deaminase (EC 3.5.4.3)" in subsystem Purine Utilization or Purine conversions (EC 3.5.4.3)

MetaCyc Pathways

• purine nucleotides degradation II (aerobic) (11/11 steps found)
• guanosine nucleotides degradation III (4/4 steps found)
• guanosine nucleotides degradation II (3/4 steps found)
• drosopterin and aurodrosopterin biosynthesis (5/7 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• superpathway of guanosine nucleotides degradation (plants) (3/6 steps found)
• purine nucleotides degradation I (plants) (7/12 steps found)
• superpathway of purines degradation in plants (11/18 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.3

Use Curated BLAST to search for 3.5.4.3

Protein Sequence (444 amino acids)

>ABZR87_RS15060 guanine deaminase (Ralstonia sp. UNC404CL21Col)
MTTMPPTSNSVHAYRGRVLHFLHDPQYRERDAYEYWEDGLLVVSDGKVVKAGDYAALRED
LPLGTQLHDYSGKLIVPGFIDTHIHFPQTDMIASPSPGLLHWLETYTFPEEHRFESEQYA
AGVASFFLDELLRNGTTSAMVWSTVHRGSAETLFTQARQRGMRMITGKVMMDRNCPEYLR
DTAESGARDTADLISRWHGKDRLAYAITPRFAPTSSEAQLQACAELAKQYKDVFIQTHVA
ENPDEVKWVADLFPNARSYLDVYDRYGLLRKGAFYGHAIWLDDGDRQRMAESGAAVAHCP
TSNLFLGSGLYNFHKNDAYRLALTLATDVGGGSSFSMLRTMGTAHKVARMGGYHLTALRM
FYLATRGAAEALGWEDRIGSFVPGAEADFIVLDPAATPLLARRNARSETLEELLFSLALL
GEDRAVSATYVQGEPAKFAVGANA