Protein Info for ABZR87_RS14730 in Ralstonia sp. UNC404CL21Col

Annotation: urease subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01792: urease, alpha subunit
  • amino acids 4 to 572 (569 residues), 967.9 bits, E=9.3e-296
• PF00449: Urease_alpha
  • amino acids 4 to 120 (117 residues), 190.4 bits, E=1.8e-60
• PF01979: Amidohydro_1
  • amino acids 126 to 459 (334 residues), 283.7 bits, E=3.6e-88

Best Hits

Swiss-Prot: 95% identical to URE1_RALSO: Urease subunit alpha (ureC) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K01428, urease subunit alpha [EC: 3.5.1.5] (inferred from 98% identity to rpi:Rpic_2184)

MetaCyc: 74% identical to urease alpha subunit (Sinorhizobium meliloti Rm2011)
Urease. [EC: 3.5.1.5]

Predicted SEED Role

"Urease alpha subunit (EC 3.5.1.5)" in subsystem Urea decomposition (EC 3.5.1.5)

MetaCyc Pathways

• urea degradation II (1/1 steps found)
• superpathway of allantoin degradation in plants (4/8 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Atrazine degradation
• Purine metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.5

Use Curated BLAST to search for 3.5.1.5

Protein Sequence (572 amino acids)

>ABZR87_RS14730 urease subunit alpha (Ralstonia sp. UNC404CL21Col)
MTLKINRRAYAEMFGPTTGDRVRLADTELIVEVERDFTLYGEEVKFGGGKVIRDGMGQSQ
RESKDCADTVITNALIIDHWGIVKADIGLKHGRISAIGKAGNPDIQPGVTIVIGPGTEII
AGEGMIVTAGGVDSHIHFICPQQIDEALNSGVTTMIGGGTGPATGTYATTCTPGPWYMQR
MLQAADAYPMNIGFLGKGNGSLPGALREQIDAGAIGLKLHEDWGSTPAAIDCCLGVADDT
DTQVAIHTDTLNESGFVEATVAAFKGRTIHTYHTEGAGGGHAPDIIRVCGESNVLPSSTN
PTRPFTVNTLDEHLDMLMVCHHLDASIAEDIAFAESRIRRETIAAEDILHDLGAFSMISS
DSQAMGRVGEVVLRTWQTAHKMKVQRGKLAGDPNDARGGHDNFRVKRYVAKYTINPALTH
GIAHEVGSVEVGKWADLVLWKPAFFGVKPSLILKGGMIASAAMGDANASIPTPQPVHYRP
MFGSAGGARGRTSLTFLSQSAAAAGVAEQYGLAKTTAVVKGTRTVSKADMIHNDWRPDIT
VDPETYQVVADGTVLTCEPAEVLPMAQRYFLF