Protein Info for ABZR87_RS14115 in Ralstonia sp. UNC404CL21Col

Annotation: ATP-dependent zinc metalloprotease FtsH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 628 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 100 to 121 (22 residues), see Phobius details PF06480: FtsH_ext" amino acids 11 to 92 (82 residues), 48.3 bits, see alignment E=3.1e-16 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 105 to 591 (487 residues), 772.7 bits, see alignment E=8.1e-237 PF06068: TIP49" amino acids 180 to 223 (44 residues), 24.3 bits, see alignment 5.2e-09 PF07728: AAA_5" amino acids 189 to 310 (122 residues), 24.5 bits, see alignment E=7.2e-09 PF00004: AAA" amino acids 190 to 322 (133 residues), 161.5 bits, see alignment E=4.2e-51 PF17862: AAA_lid_3" amino acids 345 to 389 (45 residues), 56.1 bits, see alignment 6.3e-19 PF01434: Peptidase_M41" amino acids 404 to 590 (187 residues), 228.3 bits, see alignment E=2.2e-71

Best Hits

Swiss-Prot: 89% identical to FTSH_CUPMC: ATP-dependent zinc metalloprotease FtsH (ftsH) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to rpf:Rpic12D_1721)

MetaCyc: 62% identical to ATP-dependent zinc metalloprotease FtsH (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (628 amino acids)

>ABZR87_RS14115 ATP-dependent zinc metalloprotease FtsH (Ralstonia sp. UNC404CL21Col)
MNNNWFQKAAIWLVIALVLFTVFKQFDKPRTQEGVTYSQFMDDAKAGKVKRVEVQGRTLL
VTPNEGNKYSIISPGDIWMVGDLMKYGVQVTGKAEEEQGVLLTALYYLGPTLLIIVFWFY
MMRQMQGGGKGGAFSFGKSRARLIDENNNSVTFADVAGCDESKEEVVELVDFLKDPQKFQ
KLGGRIPRGVLLVGPPGTGKTLLARAIAGEAKVPFFSISGSDFVEMFVGVGAARVRDMFE
NAKKQAPCIVFIDEIDAVGRHRGAGMGGGNDEREQTLNQMLVEMDGFEANSGVIVIAATN
RADVLDKALLRPGRFDRQVYVGLPDIRGREQILKVHMRKVPIGNDVDASVLARGTPGFSG
ADLANLVNEAALFAARRNKRVVDMQDFEDAKDKIYMGPERKSAVIREEERRATAYHESGH
AVVAKLLPKADPVHKVTIMPRGWAGGLTWQLPEHDKHYAYKDTMLEEVAILFGGRAAEEV
FLGAMSTGASNDFERATKMARDMVTRYGMSDALGTMVYVDTEQDGFFGRMASKTVSEATQ
QKVDSEIRRIVDEQYALAKGLLEANRDKVEAMTAALLEWETIDADQVNDIMDGKPPRPPR
YGSTGGGSTPPGGGTPAGVSPGNVPATA