Protein Info for ABZR87_RS13240 in Ralstonia sp. UNC404CL21Col

Annotation: transcription-repair coupling factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1143 PF17757: UvrB_inter" amino acids 135 to 222 (88 residues), 80.3 bits, see alignment 3.3e-26 TIGR00580: transcription-repair coupling factor" amino acids 153 to 1079 (927 residues), 1056.7 bits, see alignment E=0 PF21132: MFD_D3" amino acids 375 to 449 (75 residues), 76.3 bits, see alignment 5.3e-25 PF02559: CarD_TRCF_RID" amino acids 478 to 534 (57 residues), 69 bits, see alignment 1e-22 PF00270: DEAD" amino acids 603 to 763 (161 residues), 87.5 bits, see alignment E=3.1e-28 PF04851: ResIII" amino acids 603 to 759 (157 residues), 37.1 bits, see alignment E=1.1e-12 PF00271: Helicase_C" amino acids 802 to 907 (106 residues), 67.7 bits, see alignment E=3.7e-22 PF03461: TRCF" amino acids 1008 to 1098 (91 residues), 97.7 bits, see alignment E=1.4e-31

Best Hits

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 76% identity to bac:BamMC406_1859)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1143 amino acids)

>ABZR87_RS13240 transcription-repair coupling factor (Ralstonia sp. UNC404CL21Col)
MSDFSLSALPAVKPGSRFVFSGLQGAADALLLARYLEQHRAAVPMLAVVCANAVDAQRLA
EELRWFAPQARVKLLPDWETLPYDNFSPHQDLISERLATLHDLQNGACDILLVPASTALQ
RVAPPSFLAAYTFFFKKGEKLDEAALKAQFTLAGYEHVSAVMRPGEYSVRGGLIDLFPMG
SPLPYRLDLFGDEIETIRSFDPDTQRSLYPVNEVRLLPGREFPMDEASRTAFRGRWREVF
EGDPTRSPIYKDIGNGVPSAGIEYYLPLFFEETATLFDYLPGATHLAFVGDIEGAVRRFW
ADTTQRYNFMRHDRERPLLQPSALYLDEEAFFVAAKPHARLVLRAEPGDAPLSLPLPNVA
VNRRAEDPLVNLESFLMRSNCRVMICAESAGRRETLAQMLAASGLHPESVADFADLMSGD
AKFVLGVAPLYQGFILGDERIALITETELYAQTVRRAGRRKQEQATAVDSMVRDLAELKI
GDPVVHSEHGIGRYQGLVSIDMGNGEEEFLHLDYDKGSKLYVPVHQLHVISRYSGADPET
APLHSLGSGQWEKAKRKAAQQIRDTAAELLNLYARRALRQGFAFPLTPEDYATFAESFGF
EETPDQAAAIAAVIGDMTSGKPMDRLVCGDVGFGKTEVALRAAFVAVMGGKQVAILAPTT
LLAEQHYQTLVDRFADWPVRIAEISRFKNKKEIDAAIEAINAGTIDIVIGTHKLLSPDVK
FDRLGLVIIDEEHRFGVRQKEALKTLRAEVDVLTLTATPIPRTLGMALEGLRDFSVIATA
PQKRLAIKTFLRREEDGVLREAILRELKRGGQVYFLHNEVETIENKRAKLEELIPEARVV
VAHGQMHERELERVMRDFVAQRANILLCTTIIETGIDVPTANTILIHRADKFGLAQLHQL
RGRVGRSHHQAYAYLLVHDVDGLTKQAQRRLEAIQQMEELGAGFYLAMHDLEIRGAGEVL
GDKQSGEISEIGFQLYTDMLNQAVKSLKAGKEPDLMAPLAATTEINLGTPALLPQDYCGD
VQERLSLYKRLANCESSETIDNIQEELIDRFGKLPPQAQSLIETHRLRIAAAPLGIRKID
TGANAVTLQFIPNPPVDAIKIIDLVQKNRQIKLAGQDRLRIENIPAEFAALTQTIRHAMR
QLA