Protein Info for ABZR87_RS13220 in Ralstonia sp. UNC404CL21Col

Annotation: peroxiredoxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00578: AhpC-TSA
  • amino acids 28 to 143 (116 residues), 94.1 bits, E=6.2e-31
• PF08534: Redoxin
  • amino acids 33 to 152 (120 residues), 50.9 bits, E=1.5e-17

Best Hits

Swiss-Prot: 40% identical to TDX_TRYBR: Thioredoxin peroxidase from Trypanosoma brucei rhodesiense

KEGG orthology group: K03386, peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC: 1.11.1.15] (inferred from 100% identity to rpi:Rpic_1900)

MetaCyc: 36% identical to peroxiredoxin-1 (Homo sapiens)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Alkyl hydroperoxide reductase protein C (EC 1.6.4.-)" in subsystem Thioredoxin-disulfide reductase (EC 1.6.4.-)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15, 1.6.4.-

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24 or 1.6.4.-

Protein Sequence (182 amino acids)

>ABZR87_RS13220 peroxiredoxin (Ralstonia sp. UNC404CL21Col)
MKTIGDKLEPFKVVGVKPGFNNHEENGESAFEDITETSFPGKWKVIFFYPKDFTFVCPTE
IVAFAKLNDDFADRDTIVLGGSTDNEFVKLAWRREHKDLNKLNQWSFADSTGALVDQLGV
REHEAGVALRATFIVDPDNVIQHVSVNNLNVGRNPDEVLRILDGLQTDELCPCNRAVGGS
TL