Protein Info for ABZR87_RS12010 in Ralstonia sp. UNC404CL21Col

Annotation: D-mannonate oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08125: Mannitol_dh_C
  • amino acids 198 to 352 (155 residues), 59.7 bits, E=1.7e-20

Best Hits

KEGG orthology group: K00041, tagaturonate reductase [EC: 1.1.1.58] (inferred from 69% identity to pna:Pnap_2069)

Predicted SEED Role

"Altronate oxidoreductase (EC 1.1.1.58)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.58)

MetaCyc Pathways

• D-galacturonate degradation I (4/5 steps found)
• superpathway of hexuronide and hexuronate degradation (5/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.58

Protein Sequence (375 amino acids)

>ABZR87_RS12010 D-mannonate oxidoreductase (Ralstonia sp. UNC404CL21Col)
MTAPILQFGTSRFLQAHVDLFVSEALDAGQALGGITVVQTTANPASAARVAALAGGAGYP
VRIRGLRDGTPVDKTVTCRAVQRALQADADWEQLRDLMATDVQVVVSNTADQGYQLDPRD
DARLIQQPSRVPRSFPAKLVALLLGRWLRQPHAPLSLFPCELIERNGDTLCATVCALARQ
WALPTAFVDWLPTHCVWANSLVDRIVSEALHPVGAVAEPYALWAIERRPGLVLPCTHPAI
VLTDELDHHERLKLFLLNAGHTFLAERWREDAHPADMTVAQAMEDARLRPELEALWHDEI
VPVFTALGKRDAAEAYLVLLRERLLNPYLAHRLADIAQNHAQKKQRRLAPIVALARQLGL
HLAQPRLNAALANPN