Protein Info for ABZR87_RS12005 in Ralstonia sp. UNC404CL21Col

Annotation: altronate dehydratase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 13 to 80 (68 residues), 42.3 bits, E=1.3e-14
• PF04295: GD_AH_second
  • amino acids 109 to 250 (142 residues), 162.2 bits, E=1.1e-51
• PF20629: GD_AH_C
  • amino acids 259 to 501 (243 residues), 338.8 bits, E=2.5e-105

Best Hits

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 74% identity to pna:Pnap_2068)

MetaCyc: 61% identical to D-arabinonate dehydratase (Herbaspirillum huttiense)
Arabinonate dehydratase. [EC: 4.2.1.5]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• D-galacturonate degradation I (4/5 steps found)
• D-arabinose degradation IV (4/6 steps found)
• D-arabinose degradation III (3/6 steps found)
• superpathway of hexuronide and hexuronate degradation (5/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)
• superpathway of pentose and pentitol degradation (17/42 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.5 or 4.2.1.7

Protein Sequence (503 amino acids)

>ABZR87_RS12005 altronate dehydratase family protein (Ralstonia sp. UNC404CL21Col)
MSDAPLILLAPDDDVAVARVALAPGAALNAALTTRDAIPAGHKVALRDIAVGQPVHKYGQ
VIGVATAPIRAGEHVHVHNIGMAHASAQHAVGHAYRATVPVDTPATFEGYVRADGRVGTR
NFIGVISSVNCSATVCRHIVQAAQAEAAAFPNVDGVVAITHGSGCGMAGNGEGLELLQRT
LRGYADHPNFAGVLIVGLGCEVNQVAPLVQMLGARTPGLFASLTIQEEGGTREAIAAGLS
MLRDMLPIANQAQRSTVPVSHLTVGLQCGGSDGYSGISANPALGAAVDLLVRHGGTAVLS
ETPEIYGAEHLLTARAATPAVADALMNRLAWWEQYTRTLGADMNNNPSPGNKAGGVTTIL
EKSLGAVAKGGSSGLMAVYEYAQPVQTHGLVFMDTPGYDPVSATGQVAGGANLICFTTGR
GSTYGCKPVPSLKLATNSTLYRHMELDMDYDCGGIVDGHLSIAQAGEALFQLMLAAASGT
RTKSELNGLGDNEFVPWQLGAVM