Protein Info for ABZR87_RS11020 in Ralstonia sp. UNC404CL21Col

Annotation: ATP-dependent RNA helicase HrpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1333 TIGR01967: RNA helicase HrpA" amino acids 44 to 1329 (1286 residues), 1626 bits, see alignment E=0 PF00270: DEAD" amino acids 80 to 231 (152 residues), 28.2 bits, see alignment E=4.5e-10 PF00271: Helicase_C" amino acids 283 to 405 (123 residues), 44.9 bits, see alignment E=3.9e-15 PF04408: HA2_N" amino acids 469 to 495 (27 residues), 30.4 bits, see alignment (E = 9.6e-11) PF21010: HA2_C" amino acids 496 to 549 (54 residues), 46.5 bits, see alignment (E = 1.3e-15) PF07717: OB_NTP_bind" amino acids 620 to 700 (81 residues), 47.5 bits, see alignment 5.2e-16 PF11898: DUF3418" amino acids 714 to 1329 (616 residues), 722.5 bits, see alignment E=1.3e-220

Best Hits

KEGG orthology group: K03578, ATP-dependent helicase HrpA [EC: 3.6.4.13] (inferred from 58% identity to azo:azo0716)

Predicted SEED Role

"macromolecule metabolism; macromolecule synthesis, modification; dna - replication, repair, restr./modif."

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.13

Use Curated BLAST to search for 3.6.4.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1333 amino acids)

>ABZR87_RS11020 ATP-dependent RNA helicase HrpA (Ralstonia sp. UNC404CL21Col)
MSDSHAQPPRPRPAAPSQKSPKDTPPPERKPGGNGRPQRRQKPTPEELAAALEARRARAN
RVPPITFPEALPVSARRDEIAEAIAANQVVIVSGETGSGKTTQLPKICLSIGRGIGAGGT
GLIGHTQPRRIAATSTAKRIAQEIGTPVGEHVGFQVRFNDTLSAGASVKLMTDGILLAET
QNDPLLRAYDTIIIDEAHERSLNIDFLIGYLKQLLPRRPDLKVIITSATIDAQRFAEHFA
GPKGPAPVIEVSGRLYPVEVRYRPIQRDEKDKERDLYEALVDAVDELAREGPGDVLIFLP
GEREIREAAEALRKHHPAHTEILPLFARLSVQEQERVFRPSNARRIVLATNVAETSLTVP
GIRYVVDTGLARVKRYSYRNKVEQLQIEPVSQAAANQRAGRCGRVADGVCIRLYDEADFI
ARPRFTDPEILRSSLAAVILRMKALRLTDVEQFPFIEPPLGRAIADGYQLLQELGAVDDE
NALTPLGKQVARLPLDPRVARMILAGRDHQCLREMLIIASALSVQDPRERPQELQQQADQ
AHRQFADEKSEFLGWVKLWKWFEEAIAHKKSNKQLQDQCRSHFLSHVRLREWRDVHSQLH
TTVAEQGWKLNESDPTYEQLHLALLTGLLGNIGVRIEEADGKGREYLGARGIKFFLWPGS
AIARKAGKWVVAGELVDTSRLFGRTLARIEPEWVEKVGAHLLKVSWSDPHWEKKAGQVMA
FERGTLYGLPIYQQRRVHFGPMQPKEAREMFIRRALVDGEFETRLPFFTHNQRLVREIEN
LEHKSRRQDVLVDDELIYAFYDSQIPADIYNTVSFERWYAEAASAGGKSGQKLLYLNRDD
LMRHEAAGITTDLFPKVLPIAGIDMGLTYHFEPGSPRDGVTLTVPLYALNQVPAQRTEWL
VPGMLKEKVHLLLKSLPQKLRRHCVPLPDYAAGFVSRVRLGDGDLLDRLIADVREQTGIA
LKRADFKLETLPAHHFMNFKVIDEHGRQLDMGRNLAQLRAELGGRAQQTFQSIAAQDAAV
AGAQNDGAKPGKAGKSGKSEAPANAALYSGLTTWNFGELPELLEVRKGNQTLFGYPALVD
AGDHCDVEVFDDPAEAARIHRLGLRRLFAIQLREPLKYLEKNIPGLSQMAIQFMNLGTQD
ELRDQILDATLERACLQDPLPTDDASFGARKDESRARLTLLAQEIARLVGAILAEYAQLP
RKLQIAKPFAAATADIDAQLKTLMHKRFIEATPYAQLTHFPRYLKGIALRIDKLKADPAR
DTQRMQEMAPLIQQYQRAEKALRVQGQGGSDPRMEEFRWMLEELRIALFAQELRTPVPMS
VKRLQKVWESMQR