Protein Info for ABZR87_RS09840 in Ralstonia sp. UNC404CL21Col

Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 640 PF13589: HATPase_c_3" amino acids 30 to 157 (128 residues), 34.5 bits, see alignment E=3.1e-12 PF02518: HATPase_c" amino acids 30 to 183 (154 residues), 26.8 bits, see alignment E=9.3e-10 PF00183: HSP90" amino acids 217 to 639 (423 residues), 429.7 bits, see alignment E=3e-132

Best Hits

Swiss-Prot: 93% identical to HTPG_RALSO: Chaperone protein HtpG (htpG) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 98% identity to rpi:Rpic_0851)

MetaCyc: 59% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (640 amino acids)

>ABZR87_RS09840 molecular chaperone HtpG (Ralstonia sp. UNC404CL21Col)
MSAPHEKMAFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDAVDKLRFEGIADPSLLEG
GGELGIRIGFDAAARTITIADNGIGMSRDEAIRNLGTIARSGTREFFSQLSGDQQKDAAL
IGQFGVGFYSAFIVADRVTVESRRAGVPAEEGVRWESTGDGEFTVDTIERAERGTTITLH
LREGEDDFLSAWRVKSVVQKYSDHISLPIQMRKEAWDEEKKAMVAQDEWETINQGSALWA
RPRADVTDDQYIAFYQHIAHENGKPLAWTHNRVEGRSEYTQLLYIPTNAPFDLWDRERRS
GLKLYVKRVFIMDDAEQLLPGYLRFVKGVIDSTDLPLNVSREILQESRDVKAIREGSTKR
VLGMLESMAESDDAAEKEKYATFWQNFGQVLKEGIGEDHANKDRIAKLLRFASTHNEDSA
QTVSLADYIGRMKEGQDKIYYVTAENWTAAKSSPHLEIFRKKGVEVLLLTDRVDEWMLSF
LHDFEEKELVSVARGDLDLGALEDEAEKAEHAKVEGEFKPLVERAKAVLGDKAKDVRITH
RLTDSPSCLVADEGDISGTLARLLKQAGQQAPDSKPVLELNPTHPLVRKLALLETVTGNE
ADRAAFEDRIHVLFDQALLAEGGALTDPAAYVQRVNRLLA