Protein Info for ABZR87_RS09795 in Ralstonia sp. UNC404CL21Col

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1051 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 386 (21 residues), see Phobius details amino acids 392 to 413 (22 residues), see Phobius details amino acids 438 to 460 (23 residues), see Phobius details amino acids 472 to 496 (25 residues), see Phobius details amino acids 541 to 562 (22 residues), see Phobius details amino acids 605 to 627 (23 residues), see Phobius details amino acids 870 to 889 (20 residues), see Phobius details amino acids 895 to 917 (23 residues), see Phobius details amino acids 924 to 943 (20 residues), see Phobius details amino acids 971 to 992 (22 residues), see Phobius details amino acids 1002 to 1026 (25 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1043 (1043 residues), 1454.6 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1026 (1026 residues), 1198.6 bits, see alignment E=0 PF03176: MMPL" amino acids 303 to 496 (194 residues), 32.6 bits, see alignment E=4.4e-12

Best Hits

Swiss-Prot: 54% identical to ACRB_ECOLI: Multidrug efflux pump subunit AcrB (acrB) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 66% identity to axy:AXYL_01445)

MetaCyc: 54% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1051 amino acids)

>ABZR87_RS09795 efflux RND transporter permease subunit (Ralstonia sp. UNC404CL21Col)
MARFFIDRPVFAWVIALAIILAGVLALPKLPVAQYPNIAPPNVSISANYPGASARTVESA
VTAIIEREMNGAPGLLYMSSSSDAAGNVSINLSFTQGTSPDLAAVEVQNRLKIVEERLPE
VVRRNGIRIEKAAENYMMYLSLTAERGRFDGIDLGDLASSDLIPQLRRVPGVGTAQLFDA
EYAMRIWPDADKLTALGLTAGDLSDAVRRYNARITVGEIGSGAVPGSAPINASVTGDDGL
TTPDAFGQIPLRADAQGRMVLLRDVARVELGGSDYLYLSRMNGKPATTIGIKLAPGANAV
GVAKRVRAVLDEAQAHFPPGVRYEVAYDSSRFVGIAIEQVVKTLLEAVVLVFLVMMLFMQ
NLRATLIPTLVVPIALLGTFAVMLPMGFSINVLTLFGLVLAIGILVDDAIVVVENVERVM
HEEGLSPREATAKAMRQISGAIVGISLVLTAVFVPMAFFGGAVGNIYRQFSLSLAVSMVF
SAFLALTLTPALCATLLKPVQAGHGAERKGFFGAFNRGFARLTARYQGGVAKLLNRTGRA
LVAYGAVIGVVVLLFTQLPTAFLPEEDTGEFMTVVMLPTGATQAQTLDVVRQAEQHFMTQ
EPAVASTLAITGFSLYGNGQNAAMLFLTLKDWKQRKGVDQHVDAVVERANAAFGKIKGAM
VMAMNSPALPELGSKPGFDLRLQDRGGAGYERLAQARDRMLAEAAKHPALSEVTFAGQGD
APQVLIDVDRKKALSMGVSIDDINRTLAVMFGSDYAGDFVYRNQVRRVIVQADGKQRVSV
EQLGRMHVRNAAGAMVPLSAFTTTKWIVGPLKLDRYNGFPAMTITGSPAPGHSSGEAMAA
MESIARGLPEGFGYEWTGQSFEERLSGAQAPALFALSILVVFLCLAALYESWSIPLAVML
VVPLGVLGALLGATLRFLPNDIYFKVGLIATIGLSAKNAILIIEVAKDLVAQGMGLIDAT
LEAARLRFRPIVMTSLAFAFGVVPLAIATGAASASQRAIGTGVLGGIIAATVLAVFLVPV
FFVVVRRVFKGSERQRRLDAAHEHETAGPAA