Protein Info for ABZR87_RS09500 in Ralstonia sp. UNC404CL21Col

Annotation: D-glycero-beta-D-manno-heptose-7-phosphate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 310 TIGR02198: bifunctional protein RfaE, domain I" amino acids 7 to 309 (303 residues), 424.1 bits, see alignment E=1.6e-131 PF00294: PfkB" amino acids 13 to 301 (289 residues), 147.1 bits, see alignment E=7.6e-47 PF08543: Phos_pyr_kin" amino acids 190 to 288 (99 residues), 35.5 bits, see alignment E=7.3e-13

Best Hits

Swiss-Prot: 59% identical to HEPPK_BORBR: D-beta-D-heptose 7-phosphate kinase (rfaE) from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

KEGG orthology group: None (inferred from 99% identity to rpi:Rpic_0784)

Predicted SEED Role

"ADP-heptose synthase (EC 2.7.-.-) / D-glycero-beta-D-manno-heptose 7-phosphate kinase" in subsystem LOS core oligosaccharide biosynthesis (EC 2.7.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.-.-

Use Curated BLAST to search for 2.7.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (310 amino acids)

>ABZR87_RS09500 D-glycero-beta-D-manno-heptose-7-phosphate kinase (Ralstonia sp. UNC404CL21Col)
MTTLASEQIHAARILVVGDMMLDRYWFGDVDRISPEAPVPVVQIKRQDERLGGAANVARN
VAALGAQAAMLGVIGDDEPGRSIETLLGESHVTGHLHRDPAVNTTIKLRVLARQQQLIRV
DFENAPTHEVLMSVLDRFSTLVPQHDVVVLSDYGKGGLTHVGKMIETSRQAGRRVLVDPK
GDDYSRYRGATMITPNRAEMRQVVGSWKSEQDLTIRAQNLRRELQLEALLLTRSEEGMTL
YTEHEVLHVSAQAREVFDVSGAGDTVIATLATLLGAGANIKEAVQYANRAGGIVVGKLGT
AVVTHAELFN