Protein Info for ABZR87_RS08765 in Ralstonia sp. UNC404CL21Col

Annotation: TolC family outer membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 478 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR01844: type I secretion outer membrane protein, TolC family" amino acids 30 to 448 (419 residues), 326.5 bits, see alignment E=1.4e-101 PF02321: OEP" amino acids 35 to 220 (186 residues), 91.8 bits, see alignment E=2.5e-30 amino acids 245 to 432 (188 residues), 95.9 bits, see alignment E=1.4e-31

Best Hits

KEGG orthology group: K12340, outer membrane channel protein TolC (inferred from 99% identity to rpf:Rpic12D_0604)

Predicted SEED Role

"Type I secretion outer membrane protein, TolC precursor" in subsystem Multidrug Resistance Efflux Pumps or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (478 amino acids)

>ABZR87_RS08765 TolC family outer membrane protein (Ralstonia sp. UNC404CL21Col)
MAARGSLVVLCCSMMPMFAWAQSQPNTAAATDLLSAYRAALANDPQFASARAQSLAQREK
LTQGRAGLLPQIGGAWSSTRIIFDQTAPAEFNKTFSSTGWTLSLSQPLFRWDRWETYKQG
EIAAQAAEASLAQAQLDLITRTAQAYFDVLNAQDTLQLATAQRDAIQQQYEQARRNFDVG
NANITDANDAQARRDAIDASVIAARSDFEIKQSALKQIIGEPVGTLAGVRPGVTIPLPEP
ASAEPWVDQARSCNLQVALAQYNLQSAERDVKKATAGHLPSVDLVAQTGHTNASGNQYLP
SLPGGARFDSSQIGVQVSIPIFAGGAIQSRVRENIALETKAANDLEFARRSAEQGARQAY
IGVIAGLAQVKALEAAELSARTAYDSNQLAYGVGVRIGTDVLNSQAQLFQARRDLARARY
DTIVNGLRLKSAAGSLTEADVIQVNTLLTANGSSDITALPPASAKPESAKPAGKSAKR