Protein Info for ABZR87_RS07955 in Ralstonia sp. UNC404CL21Col

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 526 transmembrane" amino acids 65 to 85 (21 residues), see Phobius details amino acids 216 to 237 (22 residues), see Phobius details PF08521: 2CSK_N" amino acids 70 to 214 (145 residues), 159.7 bits, see alignment E=9.2e-51 PF00512: HisKA" amino acids 292 to 355 (64 residues), 58.4 bits, see alignment E=1.2e-19 PF02518: HATPase_c" amino acids 403 to 517 (115 residues), 90 bits, see alignment E=2.8e-29 PF14501: HATPase_c_5" amino acids 407 to 495 (89 residues), 22.2 bits, see alignment E=2.2e-08

Best Hits

KEGG orthology group: K07649, two-component system, OmpR family, sensor histidine kinase TctE [EC: 2.7.13.3] (inferred from 98% identity to rpf:Rpic12D_0453)

Predicted SEED Role

"Two-component system sensor protein"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (526 amino acids)

>ABZR87_RS07955 sensor histidine kinase (Ralstonia sp. UNC404CL21Col)
MGDRLAWPWRRHRGSLRERAGTAPGADGHDDGGDGGGSLTDTLPHLEDDATRPVARSLFG
EILDWMLAPLLLLWPMSIAVTYLVAKSIANAPYDRALESSAIVLSQQLREVNGRVTLQLP
ISAREILRADETDNIYYQVLGTNGEFVSGDRDLPLPPEEDANAGGLVQLRDDHIHGTEIR
VAYTFVQRPGSGDKPALVQVAETLDKRAQLANEIIKGVILPQFVILPLAVILVWFGLTRG
LAPLNAIQERIRARNPGDTSPIDEGAAPQELTPLVASFNDLLGRLEQSVHTQKRFIADAA
HQMKTPLAGLRMQAELAQREQSPDELRRTLAHIADSSDRTAHLVKQLLSLARMENMGTTD
GMVPLDICALSRQVVADWLPKAWAKQIDLGFEEPGPPVTISGNATMLAEMLNNLLDNAIR
YTPDGGHVTVRVTTAPFEPFVFIDVDDTGPGIPVAERERVMQRFYRILGTQAEGSGLGLA
IVREIVQQHGGDIEVLDNVYQASPRLAGARFRITLHRASSGEEATA