Protein Info for ABZR87_RS06630 in Ralstonia sp. UNC404CL21Col

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 672 transmembrane" amino acids 48 to 72 (25 residues), see Phobius details amino acids 345 to 365 (21 residues), see Phobius details PF02743: dCache_1" amino acids 77 to 260 (184 residues), 49.9 bits, see alignment E=4.6e-17 PF00512: HisKA" amino acids 437 to 499 (63 residues), 28.6 bits, see alignment E=1.8e-10 PF02518: HATPase_c" amino acids 547 to 661 (115 residues), 86.1 bits, see alignment E=3.6e-28

Best Hits

KEGG orthology group: K10125, two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC: 2.7.13.3] (inferred from 98% identity to rpi:Rpic_0187)

Predicted SEED Role

"Signal transduction histidine kinase regulating C4-dicarboxylate transport system (EC 2.7.13.3)" (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (672 amino acids)

>ABZR87_RS06630 sensor histidine kinase (Ralstonia sp. UNC404CL21Col)
MHSVKHLGDMPTAGTALEGTASPSAAQLQPMSDPDFSLTSASGPRRGFWWLVALGLVVVM
TVVCATTFVVAWNRGLAQAQQAAGGRVDRYAANLKSTLDRYEYLPALVALHPFIHDLLAN
PTPANVDRANRYLREVNDRAHATATYVIAPSGKALAASNYNQPDSFVGAEYLFRPYFQQA
AEGHVGRFYGIGITREEPGYYISQPVMQDGRVIGVTVVKLNLEWFGRASHDASEPVMVAD
ENGVIFLSSVPAWQYRTVEPLTSKLQAQLEATRQYYRKQITPLPLQPEAPAFLRLTGRLP
EGAELIRVGERTNATRYLQVSRDLVEPDWTLMYLTPVEPVMGAARSATVAAAFAFAFACL
LLFYWRQRRLRMMEMLRSRRLLEAAYDQLERRVEDRTADLMATNEQLQHEIVDRTRAEAE
LRATQDELVQASKLAALGQMAAGITHELNQPLAALRTFSDNTRILLERGQHGAATDNLQA
IADLTERMGKITAQLKLFAGRSRRKVVDVQVRVALDHTLALLRPRLGDVLVELHWRIPET
EAVVRADELKLEQVLINLVGNALDAINANEPVRAGRIDIIIGPIEGAQAPSNQLSIAVRD
NGPGIPPDAMPHLFEPFFTTKEIGQGLGLGLAISTSIARDFGGSLSAANVPGGGAQFTLT
LVRADVTSAASL