Protein Info for ABZR87_RS06350 in Ralstonia sp. UNC404CL21Col

Annotation: thiol:disulfide interchange protein DsbA/DsbL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 218 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF13462: Thioredoxin_4" amino acids 44 to 195 (152 residues), 33.6 bits, see alignment E=6.3e-12 PF01323: DSBA" amino acids 49 to 195 (147 residues), 47.5 bits, see alignment E=3e-16

Best Hits

KEGG orthology group: K03673, thiol:disulfide interchange protein DsbA (inferred from 100% identity to rpf:Rpic12D_0143)

Predicted SEED Role

"Periplasmic thiol:disulfide interchange protein DsbA" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (218 amino acids)

>ABZR87_RS06350 thiol:disulfide interchange protein DsbA/DsbL (Ralstonia sp. UNC404CL21Col)
MKKLAAFLIALATGAGFLMTAPANAAPTAGKEYKVLQTPQPVPAGKIEVTEFFWYGCPHC
YDFENTWTAWVAKQGKDVVIKRVPVAFNAKLEPHTRIYYTLEALGKLDAKDASGKTLHDR
VFDQLHKNYRSMSELDDIAKFMAANGVDEKQFRDTYNSFSVNANTKRAAQLADQYKIEGV
PTVVVQGKYTTSPADAGSNVGAAQTLDYLVDQVRNRKM