Protein Info for ABZR87_RS06150 in Ralstonia sp. UNC404CL21Col

Annotation: NADP-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16884: ADH_N_2
  • amino acids 9 to 116 (108 residues), 131.9 bits, E=1.3e-42
• PF00107: ADH_zinc_N
  • amino acids 161 to 288 (128 residues), 69.2 bits, E=5.2e-23
• PF13602: ADH_zinc_N_2
  • amino acids 194 to 338 (145 residues), 57 bits, E=6.7e-19

Best Hits

Swiss-Prot: 63% identical to CURA_ECOLI: NADPH-dependent curcumin reductase (curA) from Escherichia coli (strain K12)

KEGG orthology group: K07119, (no description) (inferred from 71% identity to ank:AnaeK_3312)

MetaCyc: 63% identical to NADPH-dependent curcumin/dihydrocurcumin reductase (Escherichia coli K-12 substr. MG1655)
RXN0-6676; RXN0-6677

Predicted SEED Role

"Putative oxidoreductase YncB"

MetaCyc Pathways

• curcumin degradation (2/2 steps found)

Protein Sequence (343 amino acids)

>ABZR87_RS06150 NADP-dependent oxidoreductase (Ralstonia sp. UNC404CL21Col)
MPQREAVNRRIVLASRPSGTPSLDNFRIEETAVPTPQDGQVLLRTLYLSLDPYMRNLMDE
VGPGYAPPVEVGAPMVGGTVSRVVASRDARFREGDVVLGAAGWQDYAVAGGDELTALGDM
PEPSLALGGLGMPAFAAYVGLLDIGEPKPGETVVVAAATGAVGAVVGQIAKLKGARVVGI
AGGADKCRYAVDTLGFDACLDRRQPDLAKRLAQACPDGIDVYFENVGGEVFDAVLPLLNI
GARVPVCGFISHYNDEAAAGPDRLPKVTATVLQKRVRMQGFIILDHYASRYDAFQRDMAA
WVAAGKVKVREDRVDGLENAPAAFLGLLEGRNFGKLVVRVAEA