Protein Info for ABZR87_RS05865 in Ralstonia sp. UNC404CL21Col

Annotation: threonine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF14821: Thr_synth_N
  • amino acids 2 to 79 (78 residues), 100.8 bits, E=3.7e-33
• TIGR00260: threonine synthase
  • amino acids 95 to 434 (340 residues), 234.1 bits, E=1.3e-73
• PF00291: PALP
  • amino acids 99 to 332 (234 residues), 41.4 bits, E=1.1e-14

Best Hits

Swiss-Prot: 61% identical to THRC_METGL: Threonine synthase (thrC) from Methylobacillus glycogenes

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 71% identity to mpt:Mpe_A1542)

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• L-threonine biosynthesis (2/2 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.3.1

Use Curated BLAST to search for 4.2.3.1

Protein Sequence (470 amino acids)

>ABZR87_RS05865 threonine synthase (Ralstonia sp. UNC404CL21Col)
MRYVSTRGGSVDRRFSEILLEGLAPDGGLYVPTAYPKIDDATLRRWRGLSYAELAFEILS
LYIDDIPADALRTIIANTYTPEIFGSTQITLLRKLDDSISLLNLSNGPTFAFKDMAMQLL
GNLFEVELERRGLQLNILGATSGDTGSAAEYAMRGKRNVQVFMLSPHGRMSPFQQAQMFS
LQDENIHNLAVEGSFDTCQDIVKAVSADLGFKRQYSIGTVNSINWARLLAQVVYYFAGYF
QATTDNSERVSFCVPSGNFGNICAGHVARMMGLPIENLVLATNENDVLNEFFKTGRYRVR
TSRETMITSSPSMDISKASNFERFVFDLLGRDAQRVAQMFGTELPRYGRFTLEEHAFAQI
ASYGFVSGKSTHADRLQIISDTWERHRMMIDPHTADGVKVAREHLRPGTRTIVLETALPL
KFDEIVRQATGQDAPRPASVADLEQRPRRCRVIEPSADKVMAYIAQHCNS