Protein Info for ABZR87_RS05855 in Ralstonia sp. UNC404CL21Col

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 21 to 483 (463 residues), 545.3 bits, E=5.2e-168

Best Hits

Swiss-Prot: 54% identical to DAVD_PSEPK: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 84% identity to bge:BC1002_4549)

MetaCyc: 54% identical to NAD(P)-dependent succinate-semialdehyde dehydrogenase (Pseudomonas fluorescens)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• methylglyoxal degradation V (1/3 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• L-rhamnose degradation II (2/8 steps found)
• superpathway of fucose and rhamnose degradation (3/12 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22

Protein Sequence (490 amino acids)

>ABZR87_RS05855 NAD-dependent succinate-semialdehyde dehydrogenase (Ralstonia sp. UNC404CL21Col)
MTKSYSLRDLIRADNFIDGQWVPAASGKRFPVTDPATGKVITEVADSGPDDARAATDAAA
RAFPGWRDTLPKDRATVLRRWYALILEHTDSLARLISLEQGKPLAEGRGEVMYGASYVAW
FADEATRIYGDVIPQQQRGKRMTAIKEPVGIVAAITPWNFPLAMIARKIAPALAAGCTVV
GKPAEDTPLTALALVLLAHEAGVPAGVLNLISASRDNAVGSVKAWLDDGRVRKITFTGST
PVGKYLAQESAGTLKKLSLELGGNAPFIVFEDADLEAAVTGLMAAKFRNGGQTCVSPNRV
YVQAPVYEKFADLLATRVAALKVAPATDPNALIGPMINARAVEKIESHVKDAIDHGARVL
TGGKRLPELGKNYYAPTVLADATPNMRLSCEETFGPVVPLFRFDDEAQAIHAANDTPFGL
ATYFYSQDLRRIERIARLLEAGLVGINEGVLSSEAAPFGGVKESGYGREGSKYGLDDYLS
IKYLCQGNLE