Protein Info for ABZR87_RS05190 in Ralstonia sp. UNC404CL21Col

Annotation: 4-aminobutyrate--2-oxoglutarate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00700: 4-aminobutyrate transaminase
  • amino acids 15 to 424 (410 residues), 636.3 bits, E=9e-196
• PF00202: Aminotran_3
  • amino acids 30 to 424 (395 residues), 441.3 bits, E=1.5e-136

Best Hits

Swiss-Prot: 70% identical to PUUE_ECOLI: 4-aminobutyrate aminotransferase PuuE (puuE) from Escherichia coli (strain K12)

KEGG orthology group: K00823, 4-aminobutyrate aminotransferase [EC: 2.6.1.19] (inferred from 99% identity to rpi:Rpic_3721)

MetaCyc: 70% identical to 4-aminobutyrate aminotransferase monomer (Cupriavidus necator H16)
4-aminobutyrate transaminase. [EC: 2.6.1.19]; 2.6.1.- [EC: 2.6.1.19]

Predicted SEED Role

"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)

MetaCyc Pathways

• 4-aminobutanoate degradation I (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (3/4 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• 4-aminobutanoate degradation II (1/2 steps found)
• homotaurine degradation (1/2 steps found)
• 4-aminobutanoate degradation V (3/7 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• nicotine degradation I (pyridine pathway) (4/17 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Butanoate metabolism
• Glutamate metabolism
• Propanoate metabolism
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.19

Protein Sequence (426 amino acids)

>ABZR87_RS05190 4-aminobutyrate--2-oxoglutarate transaminase (Ralstonia sp. UNC404CL21Col)
MNARDPQQNAQWNARRLAATPRGVGVMTDRYAERAENALFWDVEGRRYIDFAAGIAVVNT
GHRHPRLVQAVREQLDHFTHTAFQIVPYGSYVELAERLNTITPGTHAKKTAFFTTGAEAV
ENAIKIARAHTGRPGVIALTGAFHGRTFMGMSLTGKVVPYKTGFGPFPGSIYHVPAPVAL
HGVSTQDALDAIQRLFKADIDPRQVAAIIFEPVQGEGGFYQMPADFVRAIRALCDEHGIV
MIADEVQTGFARTGKLFAMEHTGVLPDITTMAKGLAGGLPLSAVTGRAEIMDAPAPGGLG
GTYAGNPLAVASAHAVLDIIADEKLCERSAALGARLVEALNAAKAKQPRIAEVRGVGAMV
AVEFNTPDGKPDADFTKLVQQRALEAGLLLLSCGVYGNVIRFLFPLTIEDAVFEEGLAIL
QRALEG