Protein Info for ABZR87_RS04800 in Ralstonia sp. UNC404CL21Col

Annotation: thiazole synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 275 PF05690: ThiG" amino acids 15 to 261 (247 residues), 359.8 bits, see alignment E=3.4e-112

Best Hits

Swiss-Prot: 100% identical to THIG_RALPJ: Thiazole synthase (thiG) from Ralstonia pickettii (strain 12J)

KEGG orthology group: K03149, thiamine biosynthesis ThiG (inferred from 99% identity to rpf:Rpic12D_3321)

Predicted SEED Role

"Thiazole biosynthesis protein ThiG" in subsystem Thiamin biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (275 amino acids)

>ABZR87_RS04800 thiazole synthase (Ralstonia sp. UNC404CL21Col)
MTTTNLSAVADPLRLYDETFASRLLLGTARYPSPQSLEDAVRVSNPAMLTVALRRQSAGS
PEGGAGFWKMLRELGVPVLPNTAGCYSADEAYTLAQMSREVFETDWIKLEVIGDDYTLQP
DTLALPAAAERLIRDGFKVLPYCTEDLVLCRRLLDVGCQALMPWAAPIGTGRGPTNPYGL
RLLRERLPNVPLIVDAGLGVPSHATQVMEWGYDAVLLNTAVAQAGDPVAMAQAFAMATQA
GRLARLSGPMPERDVAQASTPVVGLPFWHAEEKQA