Protein Info for ABZR87_RS04235 in Ralstonia sp. UNC404CL21Col

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 740 transmembrane" amino acids 96 to 115 (20 residues), see Phobius details amino acids 122 to 142 (21 residues), see Phobius details amino acids 155 to 176 (22 residues), see Phobius details amino acids 188 to 204 (17 residues), see Phobius details amino acids 342 to 364 (23 residues), see Phobius details amino acids 371 to 395 (25 residues), see Phobius details amino acids 688 to 706 (19 residues), see Phobius details amino acids 712 to 730 (19 residues), see Phobius details PF00403: HMA" amino acids 14 to 71 (58 residues), 56.5 bits, see alignment 7.6e-19 TIGR01511: copper-translocating P-type ATPase" amino acids 137 to 731 (595 residues), 575.3 bits, see alignment E=3.1e-176 TIGR01525: heavy metal translocating P-type ATPase" amino acids 156 to 730 (575 residues), 617.5 bits, see alignment E=5.7e-189 TIGR01494: HAD ATPase, P-type, family IC" amino acids 197 to 450 (254 residues), 155.8 bits, see alignment E=2.7e-49 amino acids 524 to 707 (184 residues), 141.2 bits, see alignment E=7e-45 PF00122: E1-E2_ATPase" amino acids 225 to 405 (181 residues), 201.7 bits, see alignment E=1.9e-63 PF00702: Hydrolase" amino acids 422 to 642 (221 residues), 124.2 bits, see alignment E=2.2e-39

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 96% identity to rpf:Rpic12D_3217)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (740 amino acids)

>ABZR87_RS04235 heavy metal translocating P-type ATPase (Ralstonia sp. UNC404CL21Col)
MTAASLPDVTSTDLDISGMTCAACAGRVERALRAVPGVTEASVNLATERARVQGGAARDA
LVAAVTAAGYEARVASDETAAPAAAEPDFWGGAGPVWIAAALSVPLVLPMIAGWFGRDWM
LPAWVQWLLATPVQFVIGARFYKAGWKALRAGAGNMDLLVALGTSAAYGLSLWLWWRAGA
DGMHHAPHLYFESAAVVITLVRLGKWLEVRAKRQTAQAIRALQALRPDTARVRGADGTLR
DTPVAQVRVGDVVSVRAGERIPVDAVVLEGASHVDESMLTGESLPVPKREGDRVTAGAIA
TDGVLLVRTTAIGADTMLSRIIRLVEDAQAAKPPIQQLVDRVSAIFVPAVLVAALLTLAG
WFIAGAGWETAIVNAVAVLVIACPCALGLATPSAIMAGTGAGARRGILIADAQALERAQQ
VDFVVFDKTGTLTVGQPRVTAVEAASGIDADTLLDQLAALQAENTHPLAQATRDYAKERG
RAVTPAQSPEVLAGRGTRGIVNGVSLQLGNARWMDELGLDRSALQARADALEAQGNTVSW
LAQRDEGGLQLRGLIGFGDALKPGAKEAVSALQARGVRTALVTGDNAGAARSVAQALGID
EVAAQVLPQDKAARVTAWQQGGHVVAMVGDGINDAPALAAADVGIAMATGTDVAMQAAGI
TLMRGEPRLVSDALDLSRRTVAKIRQNLFWAFIYNVVGIPLAAFGLLNPTFAGAAMAFSS
VSVVTNALMLRRWRATGDNA