Protein Info for ABZR87_RS01395 in Ralstonia sp. UNC404CL21Col

Annotation: glutamate-5-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 15 to 284 (270 residues), 54.4 bits, E=4.1e-19
  • amino acids 318 to 382 (65 residues), 31.7 bits, E=3.1e-12
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 17 to 415 (399 residues), 478.1 bits, E=9.8e-148

Best Hits

Swiss-Prot: 99% identical to PROA_RALPJ: Gamma-glutamyl phosphate reductase (proA) from Ralstonia pickettii (strain 12J)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 98% identity to rpf:Rpic12D_2570)

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-citrulline biosynthesis (7/8 steps found)
• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• superpathway of L-citrulline metabolism (9/12 steps found)
• L-N^δ-acetylornithine biosynthesis (5/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (426 amino acids)

>ABZR87_RS01395 glutamate-5-semialdehyde dehydrogenase (Ralstonia sp. UNC404CL21Col)
MKQLDVNEYMALVGRQARTASRGMARAGTAQKNRALLHIAAAVRRDAAKLKEVNARDVER
ARANGQDAAFIDRLTLTDRAIETMAAGLEQIAALPDPIGEISNMKFRPTGIQVGQMRVPL
GVIGIIYESRPNVTVDAAALCIKSGNATILRGGSEAIESNGALAALIEEGLADAGLPANA
VQVVATTDRAAVGKLITMTEYVDVIVPRGGKSLIARLIEEARVPMIKHLDGICHVYIDVD
ADIEKAVRVCDNAKTQRYAPCNTMETLLVSRDVAARALPPLAKIYQDKGVELRVCPATRA
TLEAAGFGNLKDAVEADWHTEYLAPILSIRTVDGLDDAIEHINTYGSAHTDSIITENYST
GMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFG
HGEIRT