Protein Info for ABZR87_RS00870 in Ralstonia sp. UNC404CL21Col

Annotation: DNA mismatch repair endonuclease MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 635 TIGR00585: DNA mismatch repair protein MutL" amino acids 10 to 310 (301 residues), 303.3 bits, see alignment E=1.3e-94 PF02518: HATPase_c" amino acids 29 to 85 (57 residues), 33.1 bits, see alignment 1.3e-11 PF13589: HATPase_c_3" amino acids 32 to 131 (100 residues), 45.9 bits, see alignment E=1.2e-15 PF01119: DNA_mis_repair" amino acids 213 to 329 (117 residues), 133.2 bits, see alignment E=7.4e-43 PF08676: MutL_C" amino acids 449 to 591 (143 residues), 161 bits, see alignment E=3.1e-51

Best Hits

Swiss-Prot: 92% identical to MUTL_RALSO: DNA mismatch repair protein MutL (mutL) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 98% identity to rpf:Rpic12D_2430)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (635 amino acids)

>ABZR87_RS00870 DNA mismatch repair endonuclease MutL (Ralstonia sp. UNC404CL21Col)
MTSASTSRRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATHLQIKLEEGGVR
RIAITDNGGGIPADELPVALMRHATSKIGSLEELESVATLGFRGEALASIASVAELTLTS
RTANDAHATQIIAQTGRAQPASGGVGTTVDVQHLYFNTPARRKFLKTEQTELGHCMEVIR
RTALARPDVAISVHHNGKPLEHWNATQADSRSAAVLGTEFARARLPFEESAGELRLFGFA
GLPTASRGRADHQFFYVNGRFVRDRLLTHAVRSAYEDVLHGDRFPAYVLCLELPPEAVDV
NVHPSKIEVRFRDSRAVHQFVYHAVQRALSRHAGEQGDSLRTDIADAPEVAGVTTAPSPA
DNTTRWINQMAARQTSLGIAQPRAEYLSMMRGDSAPMPSGRPAWMTDVPSAATLFDGGTA
TAQAPVAVAEPAAVQHADDDDVHPLGFAVAQLHGIYVLAQNTRGMVLVDMHAAHERILYE
QLKTALEARRVEVQPLLIPVTFAASPVEIGTAEEFRDTLTLLGFDISAVSPTTLAVRSVP
TLLQKADAQALARDVLRDLQAYGGSRVLAERQNELLATLACHSAVRANRRLNLDEMNALL
RQMEATERADQCNHGRPTWIQLTVADLDRLFLRGQ