Protein Info for ABZR87_RS00285 in Ralstonia sp. UNC404CL21Col

Annotation: acetylornithine transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00202: Aminotran_3
  • amino acids 19 to 389 (371 residues), 339 bits, E=1.8e-105

Best Hits

Swiss-Prot: 96% identical to ARGD_RALSO: Acetylornithine aminotransferase (argD) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K00821, acetylornithine/N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.11 2.6.1.17] (inferred from 100% identity to rpi:Rpic_2703)

MetaCyc: 45% identical to succinylornithine transaminase (Escherichia coli K-12 substr. MG1655)
Succinylornithine transaminase. [EC: 2.6.1.81]; Acetylornithine transaminase. [EC: 2.6.1.81, 2.6.1.11]

Predicted SEED Role

"Acetylornithine aminotransferase (EC 2.6.1.11)" in subsystem Arginine Biosynthesis extended (EC 2.6.1.11)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of arginine and polyamine biosynthesis (16/17 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• L-ornithine biosynthesis I (5/5 steps found)
• L-arginine degradation II (AST pathway) (1/5 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.17

Use Curated BLAST to search for 2.6.1.11 or 2.6.1.17 or 2.6.1.81

Protein Sequence (395 amino acids)

>ABZR87_RS00285 acetylornithine transaminase (Ralstonia sp. UNC404CL21Col)
MAFADYPVQSLMYITNRPEIVFTEGKGSWLTDHNGKRYLDFVQGWAVNCLGHSNDGMIEA
LNAQAKKLINPSPAFYNEPMAKLAGLLTAHSCFDKVFFANSGAEANEGAIKLARKWGKKH
KNGAFQIITFDHSFHGRTLATMSASGKAGWDTIFAPQVPGFPKAILNDIASVEALITDET
VGVMLEPVQGEGGVLPATPEFMQQLRALTKKHKILLIVDEVQAGCGRCGTLFAYQLSNIE
PDIMTLGKGIGGGVPLSALLCTDEVASFEAGDQGGTYNGNPLMTAVGCSVIEQLLAPGFL
AGVEERGAYLRTQLLKLSEEFGLAGERGNGLLRALLLGKDIGGQLVEAAREMNPTGLLLN
APRPNILRFMPALNVTTEEIDTMIGMLRTLLKAHA