Protein Info for ABZR87_RS00030 in Ralstonia sp. UNC404CL21Col

Annotation: pantoate--beta-alanine ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 283 TIGR00018: pantoate--beta-alanine ligase" amino acids 1 to 282 (282 residues), 299.5 bits, see alignment E=1.9e-93 PF02569: Pantoate_ligase" amino acids 3 to 281 (279 residues), 333 bits, see alignment E=5.7e-104 TIGR00125: cytidyltransferase-like domain" amino acids 19 to 76 (58 residues), 31.6 bits, see alignment E=1.4e-11

Best Hits

Swiss-Prot: 99% identical to PANC_RALPJ: Pantothenate synthetase (panC) from Ralstonia pickettii (strain 12J)

KEGG orthology group: K01918, pantoate--beta-alanine ligase [EC: 6.3.2.1] (inferred from 99% identity to rpf:Rpic12D_2196)

Predicted SEED Role

"Pantoate--beta-alanine ligase (EC 6.3.2.1)" in subsystem Coenzyme A Biosynthesis (EC 6.3.2.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (283 amino acids)

>ABZR87_RS00030 pantoate--beta-alanine ligase (Ralstonia sp. UNC404CL21Col)
MKVISSIQELRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGP
NEDFDKYPRTLQDDIEKLQKEGVYVLFAPTERDMYPEPQEYRVDPPHDLGDTLEGEFRPG
FFKGVCTVVMKLFCCVQPRVAVFGKKDYQQLMIVRRMAHQFALPVDIVPAETVRADDGLA
LSSRNVYLTNEERAEAPELYRTLHQVRQDVLETVLQGQASHEEVTAKAMEYLRGRGWQPD
YVAVRRRSDLQKPTPENIAAGEPLVVLTAAKLGKTRLIDNLEI