Protein Info for ABZR86_RS21580 in Dyella japonica UNC79MFTsu3.2

Annotation: type I methionyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 4 to 249 (246 residues), 330.1 bits, E=4.5e-103
• PF00557: Peptidase_M24
  • amino acids 13 to 242 (230 residues), 183.2 bits, E=2.8e-58

Best Hits

Swiss-Prot: 60% identical to MAP1_SHIFL: Methionine aminopeptidase (map) from Shigella flexneri

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 74% identity to xal:XALc_2020)

MetaCyc: 60% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (8/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.18

Use Curated BLAST to search for 3.4.11.18

Sequence Analysis Tools

See A0A1I2IYC0 at UniProt or InterPro

Protein Sequence (254 amino acids)

>ABZR86_RS21580 type I methionyl aminopeptidase (Dyella japonica UNC79MFTsu3.2)
MAVTLKSPADIQAMREAGKLAAEVLAMLKEHVKPGVTTEDLDRLAYEHIVNVQKAIPANV
GYNGFPKTLCTSVNHVICHGIPSPGKLLKDGDIINLDVTVIRDGWHGDTSRMYYVGTPSV
LARRLVETTHEAMMLGIQAVRPGATLGDVGHAIQKHAEAAGFSVVREYCGHGIGKVYHDE
PQVLHYGKPASGLELKKGMTFTVEPMVNAGKPQTRQLPDGWTVVTKDHSLSAQWEHTIAV
TDDGFEILTPWPDA