Protein Info for ABZR86_RS19725 in Dyella japonica UNC79MFTsu3.2

Annotation: bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 711 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF13328: HD_4" amino acids 42 to 173 (132 residues), 89.4 bits, see alignment E=5.5e-29 TIGR00691: RelA/SpoT family protein" amino acids 46 to 707 (662 residues), 555.9 bits, see alignment E=6.6e-171 PF04607: RelA_SpoT" amino acids 232 to 342 (111 residues), 142.3 bits, see alignment E=1.9e-45 PF02824: TGS" amino acids 382 to 441 (60 residues), 74.7 bits, see alignment 1.2e-24 PF13291: ACT_4" amino acids 629 to 707 (79 residues), 57.8 bits, see alignment E=3.6e-19

Best Hits

KEGG orthology group: K00951, GTP pyrophosphokinase [EC: 2.7.6.5] (inferred from 59% identity to xal:XALc_2252)

Predicted SEED Role

"GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I" in subsystem Stringent Response, (p)ppGpp metabolism (EC 2.7.6.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.6.5

Use Curated BLAST to search for 2.7.6.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2JTL3 at UniProt or InterPro

Protein Sequence (711 amino acids)

>ABZR86_RS19725 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (Dyella japonica UNC79MFTsu3.2)
MVQAAPIAASSLAQWRERAVAPAPVLAQALEACAGHAGNEAECVDVLDLLAMLGCDAQTQ
AAALWFELARSKPETWAGIEPSLPPELQRLVQGQLAAEKVWALHAQQAPQSGSEGLRRLL
LAIIRDLRVVFVLLARQLAHMRAAGALPEAERVELARLTRDIHAPLANRLGIWQLKWELE
DLAFRYLQPDTYRRIAKLLDERRADREGFIRESLDQLKRSLDAAGIRAELAGRPKHIYSI
WKKMQRKALEFSDLYDIRAIRVLVGSVADCYGALGVVHTLWPHLPGEFDDYIARPKGNDY
RSLHTAVIGPHGKTLEVQIRTHEMHRVNELGVAAHWRYKEGGSADSEFEAKIAWMRRLLE
PKAESEGDLAAELHTELMEDRVYVLTPRGEVIDLPRGATVLDFAYHVHTEVGHRCRGAKV
NGRIVPLTHQPHSGDRIEILTTKLGEPSRDWLSAHHGYLNTSRAREKVRAWFRRSAHDAN
LAAGRAMFERELKRLALPAADLNKLPVHFHLKQLDDVLVALALGEITPGQIARALQEAET
PPAEMTQSQLPVASRHATLDHSALSIEGVGNLLTTLARCCQPLPGDPVRGFVTRGRGVSV
HRADCASLARLARRDPDRVIEVEWGKASAQAYEVDVEIRGYDRKGLQKDVTSVISNAGTH
IIASSSRVFVRTGEVEMRFTLRVRDFEQLSTLLARVAALPNVVDAKRIGGG