Protein Info for ABZR86_RS19555 in Dyella japonica UNC79MFTsu3.2

Annotation: fumarate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 PF05681: Fumerase" amino acids 11 to 284 (274 residues), 331.9 bits, see alignment E=2.8e-103 TIGR00722: hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type" amino acids 12 to 284 (273 residues), 219.5 bits, see alignment E=4.8e-69 PF05683: Fumerase_C" amino acids 288 to 487 (200 residues), 289.5 bits, see alignment E=1.1e-90 TIGR00723: hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type" amino acids 324 to 486 (163 residues), 161.3 bits, see alignment E=2.2e-51

Best Hits

KEGG orthology group: K01676, fumarate hydratase, class I [EC: 4.2.1.2] (inferred from 88% identity to sml:Smlt3222)

Predicted SEED Role

"Fumarate hydratase class I, aerobic (EC 4.2.1.2)" in subsystem Serine-glyoxylate cycle or TCA Cycle (EC 4.2.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.2

Use Curated BLAST to search for 4.2.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2JKV2 at UniProt or InterPro

Protein Sequence (504 amino acids)

>ABZR86_RS19555 fumarate hydratase (Dyella japonica UNC79MFTsu3.2)
MTTIKQDDLIQSVADALQYISYYHPVDYITNLAQAYEREESPAARDAMAQILINSRMAAE
GHRPLCQDTGIVTVFLKVGMNVRWDATLSLEDMVNEGVRRAYNHPDNKLRASVLADPAGK
RLNTRDNTPAVINVSIVPGDTVEVIVAAKGGGSEAKSKFAMLNPSDSIVDWVLKTVPTMG
AGWCPPGMLGIGIGGTAEKAMLLAKESLMEHIDIQELIARGPQNRIEELRLELYEKVNAL
GIGAQGLGGLTTVLDVKIKDYPTHAANLPVAMIPNCAATRHAHFTLDGSGPVMLEAPSLE
HWPKLTYDSSKGRRVDLDTITREDVASWKPGEVLLLNGKLLTGRDAAHKRMVDMLNKGEP
LPVDFKGRFIYYVGPVDPVRDEVVGPAGPTTATRMDKFTEQVLAQTGLLGMVGKAERGPA
AIEAIKQHQSVYLMAVGGAAYLVSKAIKSSRVVGFADLGMEAIYEFDVKDMPVTVAVDSA
GTSVHQTGPKEWQARIGKIPVVVA