Protein Info for ABZR86_RS19520 in Dyella japonica UNC79MFTsu3.2

Annotation: (2Fe-2S)-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01799: Fer2_2
  • amino acids 94 to 166 (73 residues), 78.9 bits, E=1.3e-26

Best Hits

Swiss-Prot: 41% identical to NICA_PSEPK: Nicotinate dehydrogenase subunit A (nicA) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K07302, isoquinoline 1-oxidoreductase, alpha subunit [EC: 1.3.99.16] (inferred from 48% identity to rpf:Rpic12D_1768)

MetaCyc: 41% identical to nicotinate hydroxylase small subunit (Pseudomonas putida KT2440)
NICOTINATE-DEHYDROGENASE-RXN [EC: 1.17.2.1]

Predicted SEED Role

"Isoquinoline 1-oxidoreductase alpha subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

MetaCyc Pathways

• nicotinate degradation I (1/6 steps found)
• superpathway of nicotinate degradation (1/18 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.17.2.1 or 1.3.99.16

Sequence Analysis Tools

See A0A1I2JEZ2 at UniProt or InterPro

Protein Sequence (177 amino acids)

>ABZR86_RS19520 (2Fe-2S)-binding protein (Dyella japonica UNC79MFTsu3.2)
MAQAQALASNPTSSITPEKVRDGIEVEINGRPFRHTGDPDMPLLWYLRDVLRLTGTKYAS
DHGLGGADLVLVDKKPVSAASVPMHELADKKVTTVEGLAAADGKLHPLQQAFVDEDAIGC
GYCTPGWLIASLDLLNRHPQPSDDQIDQLPNLCRCGCQTRVRRAIKRASAAMAGGHA