Protein Info for ABZR86_RS19235 in Dyella japonica UNC79MFTsu3.2

Annotation: phosphoribosylformylglycinamidine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01735: phosphoribosylformylglycinamidine synthase
  • amino acids 5 to 1284 (1280 residues), 1845.2 bits, E=0
• PF18076: FGAR-AT_N
  • amino acids 36 to 145 (110 residues), 96.2 bits, E=2.5e-31
• PF18072: FGAR-AT_linker
  • amino acids 166 to 215 (50 residues), 81.4 bits, see alignment (E = 1.1e-26)
• PF02769: AIRS_C
  • amino acids 423 to 577 (155 residues), 112.8 bits, E=3.6e-36
  • amino acids 828 to 952 (125 residues), 49.6 bits, E=1e-16
• PF13507: GATase_5
  • amino acids 1034 to 1285 (252 residues), 344.2 bits, E=8e-107

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (5/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (4/5 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

See A0A1I2IGA7 at UniProt or InterPro

Protein Sequence (1286 amino acids)

>ABZR86_RS19235 phosphoribosylformylglycinamidine synthase (Dyella japonica UNC79MFTsu3.2)
MIALDGQAALSPFRLERLNARLDALHRGARVQASWFVYFIDADVVPEGEQRRRLLEVLEA
KDSAAETASLWVVPRLGTISPWSSKATDILHGAGFAVRRVERGVAYQIAGLPEPGAPEYD
AMMAVLCDAMTQSVLHRIDQAGGLFLAGQPGELVHIPLGGDARAALAKANAELGLALAED
EIDYLAERYAELGRDPTDAELFMFAQANSEHCRHKVFNASWTLDGQPQDKSLFGMIKNTH
QHSPAYTLSAYKDNAAVIEGSHGKRFFTDADGIWRRHGERIDYAIKVETHNHPTAIAPWP
GAATGAGGEIRDEGATGRGAKPKAGLTGFSVSDLRIPGHPQPWEVERPLPPRMASAFEIM
RDGPLGAAAFNNEFGRPCLGGYLRTYEHETGEAGVRRGYDKPIMIAGGLANIRSEHVQKR
DIQPGHKVIVLGGPAMLIGLGGGAASSVASGTSSAELDFASVQRDNAEMERRCQQVIDSC
WSLGDNNPIVSVHDVGAGGLSNAIPELLNDAGVGGVIDLSKVPCDDPSLSPMQVWSNESQ
ERYVLGIAAERLAEFEAFCVRERCPYAVVGDATAERSLLVTDPRRNLTVIDLPMDVLFGK
APRMHRDARRVKPRIDVVPDLSGISMDEALRRVLRLPTVGSKSFLVTIGDRTVGGLNHRD
PMVGPWQVPVADCAVTIADFDGYAGEAMAMAERAPVALLSSADAARLAVGEAITNLAAAP
IASLGEVRLSANWMAAVNHPGEDAALFDAVKAVGMELCPELDISIPVGKDSLSMQTVWTD
GDQPQRTIAPVSLVITGFARVSDVRRTLTPQLRLDRGDSDLWLLDLGGGRDRLGGSALTQ
VFNRGGGVPPDLDDAKYLKGLFELVQEANAAGLLLAYHDRSDGGAIVTLLEMAFAGHCGL
EIQLEGWAEAALRALFNEELGAVVQVAQANREAFEALLVKHGLAGMSYRIGHPKEKLGIK
LFHGGEKQFAWKWTELFAAWNETSHHMQRLRDNPLGADAELEWRLDDADPGISPKLSFDP
ADDVAAPYIAKGARPRVAVLREQGVNGQVEMAAAFDRAGFDAVDVHMSDLASGRIKLADF
RGFAACGGFSYGDVLGAGRGWATSIMYNELLRAEFTAFFADASKFALGVCNGCQMLSQLK
DIIPGAQHWPKFLRNASEQYEGRVATLEVLDSPSIFFKGMAGSRIPVAVAHGEGRVSFPQ
VCSPSKSGGAVRFVDNRGRPTEHYPLNPNGSPGGLAGFTAADGRVTIMMPHPERVFRTAQ
MSWHPDHWGEDSPWMRMFRNARVWCG