Protein Info for ABZR86_RS18715 in Dyella japonica UNC79MFTsu3.2
Annotation: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 56% identical to MANC1_ECO57: Mannose-1-phosphate guanylyltransferase 1 (manC1) from Escherichia coli O157:H7
KEGG orthology group: K00971, mannose-1-phosphate guanylyltransferase [EC: 2.7.7.22] K01809, mannose-6-phosphate isomerase [EC: 5.3.1.8] (inferred from 58% identity to tbd:Tbd_1239)MetaCyc: 56% identical to mannose-1-phosphate guanylyltransferase (Escherichia coli K-12 substr. MG1655)
Mannose-1-phosphate guanylyltransferase. [EC: 2.7.7.13]
Predicted SEED Role
"Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22)" in subsystem Alginate metabolism or Mannose Metabolism (EC 2.7.7.22)
MetaCyc Pathways
- GDP-mannose biosynthesis (4/4 steps found)
- colanic acid building blocks biosynthesis (8/11 steps found)
- β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
- D-mannose degradation I (1/2 steps found)
- D-mannose degradation II (1/2 steps found)
- mannitol degradation II (2/4 steps found)
- mannitol biosynthesis (1/3 steps found)
- 1,5-anhydrofructose degradation (2/5 steps found)
- β-(1,4)-mannan degradation (2/7 steps found)
- superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (6/14 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.7.7.13, 5.3.1.8
Use Curated BLAST to search for 2.7.7.13 or 2.7.7.22 or 5.3.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1I2G9P1 at UniProt or InterPro
Protein Sequence (470 amino acids)
>ABZR86_RS18715 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase (Dyella japonica UNC79MFTsu3.2) MLIPLVLSGGSGTRLWPVSRKNLPKQFLSLMGQGTLFQQTVARTRLLPDVASPIVVASED HRFLVAEQLLESGIQDATIVLEPLPRNTAPAIALGALQAVGQDPEALLLVLPADHLIGDE DSFRDAVEQALPAARDNWLVTFGIRPDRPETGFGYIRRGDAIGGHAYKVAEFVEKPALET AQGYIEHGGYDWNSGMFLFKAARFLDELAAHAPAMLQAVRAAHASAKADLDFVRVDADAF AQVPENSIDYAVMEKTRHAAVIPVSCAWSDIGSWSALWLAGVRDAQDNLREGDTIAIKTH RSLLRSHDRHLLATVGVDDLIVVTTPDATLVAHRDAAQDVKRVVDELKAAGRTEHSLHRV VRRPWGSYDSLESADRFQVKRIVVKPGAALSLQKHHHRAEHWIVVSGTAEVTCDDKVFLL GENQSTYIPLGSVHRLRNPGKVPLEIIEVQSGSYLGEDDIVRLEDVYGRS