Protein Info for ABZR86_RS18415 in Dyella japonica UNC79MFTsu3.2

Annotation: tryptophan--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 TIGR00233: tryptophan--tRNA ligase" amino acids 1 to 332 (332 residues), 295.4 bits, see alignment E=2.9e-92 PF00579: tRNA-synt_1b" amino acids 3 to 234 (232 residues), 169.3 bits, see alignment E=6.4e-54

Best Hits

Swiss-Prot: 68% identical to SYW_BORPA: Tryptophan--tRNA ligase (trpS) from Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

KEGG orthology group: K01867, tryptophanyl-tRNA synthetase [EC: 6.1.1.2] (inferred from 70% identity to bpt:Bpet1839)

Predicted SEED Role

"Tryptophanyl-tRNA synthetase (EC 6.1.1.2)" (EC 6.1.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2JKS1 at UniProt or InterPro

Protein Sequence (456 amino acids)

>ABZR86_RS18415 tryptophan--tRNA ligase (Dyella japonica UNC79MFTsu3.2)
MRTRVLTGITTTGTPHLGNYVGAIRPAVAASLRPEVDAFYFMADYHALIKSDDPARIERS
RLEIAATWLAAGLDPDRVTFYRQSDIPEIPELTWFLTCVTAKGLLNRAHAYKAAVDKNSE
AGEDADAGVTAGLYMYPVLMAADILAFDAHKVPVGRDQIQHIEMARDIAQRFNHIYGRDY
FVLPEVVIEEQVATLPGLDGRKMSKSYDNTIPLFAGGQKHLRDSIMRIVTDSRLPGEAKD
PDSSSLFTIFRAFATEAEAGAFHQALLDGIGWGEAKQVLFERIEADVAPMRERYDELMAR
PERIEAILREGALKARAIAAPKIAALRDAIGLRSGALVAAAPAPAVGKAEGRAGKLPRFA
SFREADGSFRFRLFSAEGEELLLSKSFADPKAAGAWQKKLKGPGAIAAVLQVQPRALHLE
LDGEFVGSTPEYGDEPARDGALTRLREALDQLSAQE