Protein Info for ABZR86_RS17470 in Dyella japonica UNC79MFTsu3.2

Annotation: penicillin-binding protein 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 669 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details TIGR03423: penicillin-binding protein 2" amino acids 21 to 611 (591 residues), 695.2 bits, see alignment E=3.9e-213 PF03717: PBP_dimer" amino acids 65 to 234 (170 residues), 149.8 bits, see alignment E=1.2e-47 PF00905: Transpeptidase" amino acids 268 to 607 (340 residues), 231.4 bits, see alignment E=1.4e-72

Best Hits

Swiss-Prot: 42% identical to MRDA_ECOLI: Peptidoglycan D,D-transpeptidase MrdA (mrdA) from Escherichia coli (strain K12)

KEGG orthology group: K05515, penicillin-binding protein 2 (inferred from 45% identity to pfl:PFL_5452)

MetaCyc: 42% identical to peptidoglycan DD-transpeptidase MrdA (Escherichia coli K-12 substr. MG1655)
Serine-type D-Ala-D-Ala carboxypeptidase. [EC: 3.4.16.4]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.16.4

Use Curated BLAST to search for 3.4.16.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2JVW4 at UniProt or InterPro

Protein Sequence (669 amino acids)

>ABZR86_RS17470 penicillin-binding protein 2 (Dyella japonica UNC79MFTsu3.2)
MALRRRSIKDSRGEAALFRARAFVGFALILLGLSVLAVRYSFLQVQRHDEFALRSENNRV
KPRAIPPARGLIFDRSGVLLADNVPAFRLEVVPEQVPDMQAMLAGIREVIPLGDDDLEAF
RKQLRQNRRFDSVPLKLHLTEDEIARFAINRWRFPGLDVVPYLTRRYPYGPLFAHVIGYV
GRIDADDLNRLDPDRYKGTSHVGRSGLERSYEDMLHGEPGYELVEVNADGRLQRVLETHA
PKPGKNLYLSIDARVQKAAMDAFAGRPGSAVAIDPRNGQVMAMVSVPSYDPNLFVNGISK
TDYTAYTSAEDKPLLNRALKSAYPPGSTVKPFLALGGLEYGVRRPEDTVLSTGEFCIPGQ
QRCYRDDKRGGDGVVNMVRAIQHSTNTYFYKLALDLGIDRLSAWMGSLGFGHKTGIDLLG
EAEGILPSREWKATRSKFGWFPGETILAGIGQGYWNVTTLQLAHATATFAGHGTPYAPRL
VMATSAVKESRVPLPNPPSGPSLIHKDNYWNVVNQGMEAVITEGTGKGQFTGFPYVVAGK
SGTAERFSRRSNDYDNNKNTAYLATRHRAWFIGYTPTDSPRIAIAAMLEQGAWGASDAGP
IVRKIMEAWLASQGGAVPARTAPEASAPALPASAPEVPEDTPVATPADVPAQLPSDHDDS
GQQDDGGHQ