Protein Info for ABZR86_RS17400 in Dyella japonica UNC79MFTsu3.2

Annotation: acetylornithine transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00707: transaminase, acetylornithine/succinylornithine family
  • amino acids 18 to 404 (387 residues), 474.2 bits, E=1.3e-146
• PF00202: Aminotran_3
  • amino acids 26 to 404 (379 residues), 399 bits, E=2.1e-123
• PF00155: Aminotran_1_2
  • amino acids 176 to 332 (157 residues), 22.4 bits, E=6.4e-09

Best Hits

Swiss-Prot: 74% identical to ARGD_XANCP: Acetylornithine aminotransferase (argD) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

KEGG orthology group: K00821, acetylornithine/N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.11 2.6.1.17] (inferred from 76% identity to xal:XALc_0776)

MetaCyc: 49% identical to N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (Escherichia coli K-12 substr. MG1655)
Succinyldiaminopimelate transaminase. [EC: 2.6.1.17]; Acetylornithine transaminase. [EC: 2.6.1.17, 2.6.1.11]

Predicted SEED Role

"Acetylornithine aminotransferase (EC 2.6.1.11)" in subsystem Arginine Biosynthesis extended (EC 2.6.1.11)

MetaCyc Pathways

• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
• aspartate superpathway (21/25 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (9/9 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• L-arginine biosynthesis I (via L-ornithine) (8/9 steps found)
• L-ornithine biosynthesis I (5/5 steps found)
• L-arginine biosynthesis II (acetyl cycle) (8/10 steps found)
• superpathway of arginine and polyamine biosynthesis (12/17 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.11

Use Curated BLAST to search for 2.6.1.11 or 2.6.1.17

Sequence Analysis Tools

See A0A1I2JV70 at UniProt or InterPro

Protein Sequence (411 amino acids)

>ABZR86_RS17400 acetylornithine transaminase (Dyella japonica UNC79MFTsu3.2)
MHAQDSSSSLIDLGKRYWLPVYRPREVVLDHGKGARVWDTEGRDYVDLGAGIAVNALGHQ
DPDLVDALVTQARKLWHSSNVFYTEPPLHLAEELVQASGFAERVFLCNSGTEANEAAIKL
VRKWAASKGRAPEQRVILTFRGSFHGRTLAAVTATAQPKYQENYEPLPGGFRYLDFNDVA
GLEAAFAQGDVAAVMLEPVQGEGGVLPASPAFIRRARELCDTHEALLVLDEIQCGMGRTG
TLFAHAQDGVTPDIVTLAKALGCGFPIGAMLAGPKVAEVMQYGAHGTTFGGNPMAAAVAR
VALRKLASAELMANVAKQAQALRDGLAAIDGELKLFAEVRGRGLMLGAVLAEAYKGRAGE
VLDHAAAHGLLVLQAGPDVLRFVPPLNITDADLAEGLARLRAALADFVGKR